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BioPharmaSpec to expand in-house analytical capabilities
For characterising higher order protein structure and accurately defining CQAs of biopharmaceuticals...
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Protein
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A new bioinformatics tool to decipher evolutionary biology
Understanding evolution is one of the cornerstones of biology - evolution is, in fact, the sole explanation for life's diversity on our planet. Based on the evolution of proteins, researchers may explain the emergence of new species and functions through genetic changes or how enzymes with novel functions might be…
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Scrib protein identified as a natural suppressor of liver cancer
A protein that typically helps keep cells organised and on task becomes a tumour suppressor in the face of liver cancer, scientists say.
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Shedding light on the brakes of Akt activity
Changes leading to the hyperactivation of the protein kinase Akt are observed in 50% of all tumours. Understanding Akt’s regulatory mechanisms is therefore essential for developing and improving cancer therapies....
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Scientists uncover mechanism allowing bacteria to survive the human immune system
Researchers have uncovered molecular details of how pathogenic bacteria fight back against the human immune response to infection.
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Tuberculosis: Researchers uncover how bacteria burst our cells
Scientists unveil the complex molecular structure that causes lethal infections by Mycobacterium tuberculosis (Mtb). Their findings might have implications for potential therapies against antibiotic-resistant tuberculosis.
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Developability assessment of therapeutic antibodies
Developability assessment is a broad term covering the evaluation of potential therapeutic candidates’ drug-like properties, manufacturability and safety profile. It is important to carry out this assessment as early as possible in the pre-clinical stage development to select the candidate with the most stable profile. This can minimise the risks…
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Scandinavian programme launched to produce all human secreted proteins
A new research programme has been launched to produce all the human secreted proteins in mammalian cell factories. The programme aims to facilitate studies of this important class of proteins, which are involved in many human diseases.
webinar
Simultaneous detection of GPCR second messengers in living cells
20 February 2017 | By BMG Labtech GmbH
Due to their role in signal transmission from the outside to the inside of a cell, G-protein coupled receptors (GPCRs) are prominent drug targets.
news
TSRI scientists use ligands to turbocharge drug discovery
Ligands are useful tools for studying how proteins work in cells and could lead to the development of new drugs.
news
New avenue for anti-depressant therapy discovered
Researchers have made a ground-breaking discovery revealing new molecular information on how the brain regulates depression and anxiety.
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Practical application of in vivo optical imaging in biotherapeutic biodistribution analyses
As advances in protein engineering technology have led to the production of novel and more structurally complex biopharmaceuticals, the ability of these drugs to smoothly traverse the body and arrive at their intended target site has become more unpredictable...
whitepaper
Whitepaper: Applications of Bio-Plex Pro™ cell signaling Akt and MAPK assay panels in signal transduction pathways
In this whitepaper, discover the applications of Bio-Plex Pro cell signalling Akt and MAPK assay panels in signal transduction pathways...
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Novo Nordisk and Aarhus University team up for protein technology R&D
1 July 2016 | By Victoria White, Digital Content Producer
Novo Nordisk and Aarhus University's Science and Technology faculty are to collaborate to strengthen protein technology research and development...
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Mechanism-informed phenotypic screening – the missing link for cancer drug discovery?
Cancer cells exhibit huge phenotypic diversity, with many well-defined phenotypes, such as invasion, deregulated proliferation and immune evasion, contributing to disease outcomes, making them uniquely amenable to phenotypic screening1...
