whitepaper
Whitepaper: Affimer® reagents facilitate affinity chromatography purification of proteins
Purification of tag-free proteins, a vital step for many research and industrial applications...
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Protein
article
Computational methods for drug repositioning
Bioinformatics and computational techniques are now experiencing increased attention as a means of improving the costly and time-consuming drug development process...
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The relevance of homogeneous radiometric assays in modern drug discovery
In the past two decades, several alternative, non-radiometric assay formats have been developed for the high-throughput screening (HTS) of target classes such as protein kinases, which were previously screened using radiometric assays. Radiometric screening (and the expertise to perform such HTS) has thus declined in recent years...
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Antibody fragment technology and avian IgY antibodies: a powerful combination
Recombinant monoclonal antibodies or antibody biologics have been successfully developed as diagnostic and therapeutic agents...
news
An interview with Bernardo Perez-Ramirez, Sanofi, speaker at the 9th Annual Proteins & Antibodies Congress, 18-19 April 2016, London, UK
13 January 2016 | By Oxford Global
In anticipation of our Proteins and Antibodies Congress, Bernardo Perez-Ramirez spoke to us about his research and his expectations...
news
New £3.4 million project to investigate protein-protein interactions
15 December 2015 | By Victoria White
There are thought to be as many as 600,000 protein-protein interactions that could be targets for new drugs. The project seeks to analyse and categorise the important features of these interactions...
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Analysing recombinant proteins by mass spectrometry
The drug discovery landscape is changing: no longer limited to big pharma, it is now within reach of academics and small consortia alike. Regardless of the setting, drug discovery requirements are always the same: strong biological theory, good chemical starting material and high quality protein samples from which to determine…
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Investigation of venom use in stem cell differentiation
Stem cells differentiate to form more than 200 specialised cells, including erythroid bodies, haematopoietic cells, myogenic cells, neural cells, signalling cells and structural cells, such as hepatocytes. Differentiation of stem cells triggers a number of variable changes in the cell, such as membrane potential, responsiveness to signal, metabolic activities, and…
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LC3 – Autophagy’s achilles’ heel?
Autophagy is a cellular homeostatic process regulating protein turnover as well as eliciting a stress response to starvation, chemical agents and pathogen infection. It has been implicated in the initiation and progression of several diseases, including neuro-degenerative disorders, Crohn’s disease, infections and cancer...
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Heat shock proteins: A high content assay opportunity to measure cellular stress response
Heat shock proteins (HSPs) have been proposed as therapeutic targets for novel anticancer agents. However, candidates have thus far failed due to low tolerability, limiting their efficacy. This failure highlights our current inability to predict drug toxicity in patients, a Holy Grail in modern drug discovery. Paradoxically, the fundamental role…