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Latest developments in COVID-19 research
As COVID-19 continues to evolve, researchers are still on the lookout for new ways to protect against the virus. Drug Target Review brings you some of the most recent pre-clinical developments.
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Five recent cell and gene therapy discoveries
This article highlights five of the latest findings using cell and gene therapy techniques that could be used in the development or design of new therapies.
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New therapeutic strategy could reduce cardiovascular disease in cancer survivors
US researchers have discovered that cancer treatments or anthracycline drugs, cause cardiovascular disease by activating a key inflammatory signalling pathway.
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Why are women more likely to get Alzheimer’s?
US researchers find that a modified immune protein harming brain connections is much more common in the brains of women with Alzheimer’s, compared to men.
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Rapidly transitioning from in silico hits to leads on ‘undruggable’ pain targets
Opioid addiction is an ongoing crisis in the US. Researchers have identified a key regulator that shapes analgesic and aversive outputs of kappa opioid receptor signalling, finding lead inhibitors of this previously ‘undruggable’ target class – the Regulators of G protein Signalling (RGS proteins) – to help re-establish non-addictive kappa…
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Novel gene therapy offers potential treatment for FCMD
Japanese researchers proposed using RNA interference for correcting a mistake in the genetic code of patients with Fukuyama Muscular Dystrophy (FCMD).
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The future of drug development: AI tailors artificial DNA
Swedish researchers have designed synthetic DNA that controls a cells’ protein production using AI.
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Researchers find breast cancer protein that could predict chemotherapy sensitivity
Researchers have identified a protein that, when present in high amounts in breast cancer tumours, is an indicator of whether DNA-damaging therapies will work or not.
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Highlights from PEGS Europe’s Protein & Antibody Engineering Summit
Drug Target Review’s Ria Kakkad recently travelled to Barcelona to attend PEGS Europe’s Protein and Antibody Engineering Summit. In this article, she shares her highlights from the event.
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Novel synthetic peptides could suppress formation of harmful amyloid aggregates
German researchers have designed peptides that bind to amyloidogenic proteins linked to Alzheimer’s and type 2 diabetes, to effectively suppress both cytotoxic amyloid aggregation and amyloid cross-accelerating interactions.
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Could beer help protect against Alzheimer’s disease?
Researchers have found that beer hop compounds can inhibit the clumping of proteins associated with Alzheimer's disease.
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Researchers find activating NPGPx protein could heal diabetic wounds
The NPGPx protein is active in foetuses, but largely dormant and absent in diabetic adults.
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New treatment target discovered for sleep apnoea
A recent study in mice revealed that an ion channel already proven to affect blood pressure in obese mice plays a role in suppressing their breathing, influencing sleep apnoea.
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Simcere receives clearance to investigate a bi-functional fusion protein drug
The FDA has cleared the Simcere's investigational new drug application for SIM0237, an anti-PD-L1/IL-15 bi-functional fusion protein, for the treatment of adult patients with advanced solid tumours.
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Newly discovered GPCR signalling process opens possibility for novel therapies
US researchers have found that G protein-coupled receptors function in a way not previously known, which suggests untapped potential.