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Drug Target Review – Issue #4 2017
Issue 4 of Drug Target Review looks at artificial intelligence in drug discovery and features In-Depth Focuses on Screening, Hit to Lead and Informatics.
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Proteogenomics
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APC protein affects immunity by preventing pre-cancerous inflammation
Mutations in the APC gene, harm the immune system, leaving it unable to tackle inflammation thereby favouring the development of cancer...
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Bacterial proteins show promise for a gonorrhoea vaccine
Researchers have identified a pair of bacterial proteins that show promise as the basis for a gonorrhoea vaccine...
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Discovery improves understanding of cellular ageing and cancer development
A team of researchers has discovered the role of the protein ZBTB48 in regulating both telomeres and mitochondria, key players involved in cellular ageing.
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Drug developed for arthritis could be first to stop heart valve calcification
The first drug to treat calcification of heart valves may be one originally designed for rheumatoid arthritis.
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Alzheimer’s, Parkinson’s, and Huntington’s diseases share common crucial feature
A study has found that abnormal proteins found in Alzheimer's disease, Parkinson's disease, and Huntington's disease all share a ability to cause damage...
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DFG €66 million funding for 15 new research training groups
The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is establishing 15 new Research Training Groups to further support early research...
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Spread of tau protein measured in the brains of Alzheimer’s patients
In a new study researchers measured how deposits of the pathological protein tau spread through the brain over the course of Alzheimer’s disease.
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A new bioinformatics tool to decipher evolutionary biology
Understanding evolution is one of the cornerstones of biology - evolution is, in fact, the sole explanation for life's diversity on our planet. Based on the evolution of proteins, researchers may explain the emergence of new species and functions through genetic changes or how enzymes with novel functions might be…
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Scrib protein identified as a natural suppressor of liver cancer
A protein that typically helps keep cells organised and on task becomes a tumour suppressor in the face of liver cancer, scientists say.
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Tuberculosis: Researchers uncover how bacteria burst our cells
Scientists unveil the complex molecular structure that causes lethal infections by Mycobacterium tuberculosis (Mtb). Their findings might have implications for potential therapies against antibiotic-resistant tuberculosis.
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Changes in RNA splicing: a new mechanism for genetic risk in schizophrenia
New research has identified sections of DNA associated with altered regulation of gene expression underlying schizophrenia.
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Proteogenomics provides new inroads to ovarian cancer treatments
29 June 2016 | By Victoria White, Digital Content Producer
Scientists have examined the proteomes of 169 ovarian cancer patients to identify critical proteins expressed by their tumours...