news
Biomarkers for predicting COVID-19 disease severity
Scientists have created a prognostic classification model which uses biomarkers to help predict an individual’s risk of developing severe COVID-19 symptoms.
List view / Grid view
Proteomics
news
New SARS-CoV-2 strain identified in South East England
UK Health Secretary Matt Hancock has said there is a mutated form of SARS-CoV-2 that may be causing a rise in infections in South East England.
news
Protein identified as potential target for leishmaniasis vaccines
New research has demonstrated in mouse models that the SHP-1 protein limits the capacity of dendritic cells, making it a target for a leishmaniasis vaccine.
article
The Editors’ views: Drug Target Review’s 2020 round-up
The Junior Editors of Drug Target Review, Victoria Rees and Hannah Balfour, discuss some of the most noteworthy news and announcements from this year.
news
Triggering an IgA response could increase COVID-19 vaccine efficacy
Two new studies suggest that SARS-CoV-2-specific IgA antibodies are more neutralising and therefore COVID-19 vaccines should encourage an IgA response.
news
Proteomics study to investigate plasma proteins in 53,000 participants
Next-generation sequencing will be employed to study 1,500 plasma proteins in participants, according to UK Biobank.
news
Novel target for pulmonary fibrosis identified using tissue from COVID-19 patients
Study suggests reducing the expression of the methyl-CpG-binding domain 2 (MBD2) protein on macrophages could be a viable therapeutic strategy for lung fibrosis.
news
Researchers provide new insights into SARS-CoV-2 lung pathology
The new study shows how SARS-CoV-2 significantly remodels cellular processes in just an hour and identifies potential drug targets and therapeutics for COVID-19.
news
New virus-like probes could make COVID-19 tests more accurate and reliable
The novel probes, known as positive controls, could make it easier to validate rapid, point-of-care diagnostic tests for COVID-19 across the globe.
news
Researchers identify a novel tau aggregation control mechanism
According to researchers, the more small tau protein variants expressed by neurons, the slower neurofibrillary tangles form.
news
Breakthrough in AI protein structure and folding prediction
An artificial intelligence (AI) system called AlphaFold has been developed to effectively predict protein structures and folding.
article
Tweaking synonymous sites for gene therapy and vaccines
Professor Laurence D Hurst explains why understanding the nucleotide mutations in viruses, including SARS-CoV-2, can have significant implications for vaccine design.
news
New ‘smart’ cell therapies show promise in solid tumours
By combining machine learning and T-cell engineering researchers were able to develop cell therapies that can selectively and effectively target and destroy solid tumours.
news
CARD8 protein could be novel atherosclerosis drug target
Researchers demonstrate that the CARD8 protein plays a key role in regulating the inflammation that causes atherosclerosis and other inflammatory diseases.
article
Investigating cellular pathways driving severe COVID-19 with proteomics
Researchers from Massachusetts General Hospital have studied several thousand circulating proteins within the plasma proteome of symptomatic COVID-19 patients and acutely ill non-COVID-19 controls. Nikki Withers discussed their findings and implications of the study with one of the lead authors, Dr Mike Filbin.