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Proteomics

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Study reveals roles of antibodies in SARS-CoV-2 disease severity

15 October 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that the level of antibodies in the serum of SARS-CoV-2 patients correlated with disease severity.

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Over 200 molecules and genes linked to COVID-19 severity

14 October 2020 | By Victoria Rees (Drug Target Review)

A team has identified 219 molecules and genes that influence the severity of COVID-19 in patients, providing information that could aid the development of therapeutics.

Wasp on a wooden platform [Credit: University of Pennsylvania].

news

Novel antimicrobial molecules derived from wasp venom

13 October 2020 | By Hannah Balfour (Drug Target Review)

Altering the mastoparan-L (mast-L) peptide found in Vespula lewisii wasp venom, researchers created several novel antimicrobial molecules.

news

Researchers uncover drivers of memory B cell formation

13 October 2020 | By Hannah Balfour (Drug Target Review)

The team demonstrated that expression of Bach2 protein and reduced mTORC1 activity is necessary for germinal B cells to become memory B cells.

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COVID-19 vaccines should not be affected by SARS-CoV-2 mutations, researchers say

12 October 2020 | By Victoria Rees (Drug Target Review)

A common SARS-CoV-2 mutation known as D614G should not impact on the efficacy of COVID-19 vaccines, a study has shown.

SARS-CoV-2 particles in grey and red - SARS-CoV-2 is the virus that causes COVID-19

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Researchers suggest blocking factor D protein could combat SARS-CoV-2

9 October 2020 | By Victoria Rees (Drug Target Review)

A team has said that inhibiting the factor D protein could prevent SARS-CoV-2 from turning the immune system against healthy cells.

EEG waves indicating an epileptic seizure overlaid with a brain

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Single-nucleus transcriptomics reveals novel epilepsy targets

8 October 2020 | By Hannah Balfour (Drug Target Review)

Study reveals which neurons are most affected by epilepsy, presenting novel targets for seizure drug discovery and development.

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SARS-CoV-2 mechanism of infection revealed using cryo-electron microscopy

8 October 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that the surface of SARS-CoV-2 can take on at least 10 different structural states when in contact with ACE2.

Syringe drawing liquid from a vial labelled 'REMDESIVIR', on a background of abstract SARS-CoV-2 particles [Credit: ffikretow@hotmail.com / Shutterstock.com].

news

Researchers identify a potential remdesivir resistance mechanism in SARS-CoV-2

8 October 2020 | By Hannah Balfour (Drug Target Review)

Exploring how the Ebola virus develops remdesivir resistance has highlighted a mutation that could allow SARS-CoV-2 to do the same.

Ovarian cancer cells forming a cancer spheroid as they grow within the peptide-protein co-assembling material [Credit: Alvaro Mata].

news

Novel tumour spheroids could improve ovarian cancer treatments

5 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers have developed a new self-assembling three-dimensional (3D) ovarian cancer tumour model to recreate the in vitro disease more accurately.

stand of DNA behing a side on view of the human head with the brain highlighted in red

news

Epigenetic marks could be the target of future Alzheimer’s therapies

2 October 2020 | By Hannah Balfour (Drug Target Review)

New findings suggest that late-onset Alzheimer's Disease (AD) is driven by epigenetic changes in the brain.

news

Antibodies from recovered COVID-19 patients inhibit SARS-CoV-2 infection in cells

28 September 2020 | By Victoria Rees (Drug Target Review)

Pre-clinical studies in cells and hamsters have shown that potent antibodies from COVID-19 patients can prevent infection from SARS-CoV-2.

news

Interactive 3D model of SARS-CoV-2 surface released

25 September 2020 | By Victoria Rees (Drug Target Review)

A new interactive map of the surface of SARS-CoV-2, featuring the Spike, Envelope and Membrane proteins, has been released for researchers to use.

SARS-CoV-2 viral particle in crosshares with words 'target locked' above

news

Experimental antiviral AR-12 could be a promising COVID-19 treatment

23 September 2020 | By Hannah Balfour (Drug Target Review)

Scientists have demonstrated that AR-12 can inhibit SARS-CoV-2 replication and are working to initiate clinical trials evaluating the antiviral drug.

news

Researchers discover druggable pocket on SARS-CoV-2 Spike protein

22 September 2020 | By Victoria Rees (Drug Target Review)

A pocket in the SARS-CoV-2 Spike protein has been discovered by researchers, who say it could be a drug target for COVID-19.

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Proteomics