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Researchers work to create a COVID-19 viral epitope map
The team used data from SARS-CoV to identify possible viral epitopes that vaccines could include to stimulate an immune response.
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Proteomics
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Copper ions could be key to blocking cancer metastasis
Researchers have identified that copper ions and their protein transporters, such as Atox1, are key to cancer cell movement and could be targeted by therapies.
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Muscle cell atlas developed to aid muscular disease and injury research
Researchers have created a new technical resource atlas which maps the 15 distinct cell types involved in muscle repair for disease and therapy research.
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Antibodies stimulate microglia to degrade Alzheimer’s amyloid plaques
A novel antibody has been shown to stimulate microglia to degrade amyloid plaques in a murine model of Alzheimer’s disease.
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Proteins vital for hepatitis B infection discovered by researchers
A new study has revealed five factors and proteins that hepatitis B infection needs for replication of its DNA, providing insight into the disease.
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Researchers identify enzyme critical for regulating cell signalling
An enzyme that adds a cell-signalling code to proteins has been identified by researchers, who say their discovery could aid in the development of cancer therapies.
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Brain Atlas enables exploration of the brain proteome
International researchers have analysed nearly 1,900 brain samples to create the Brain Atlas, the latest database released by the Human Protein Atlas (HPA) project.
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Scientists demonstrate how COVID-19 infects human cells
Researchers have used cryogenic electron microscopy to show that coronaviruses enter human cells through an interaction with angiotensin-converting enzyme 2 (ACE2).
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Mass spectrometry approach allows researchers to make precise protein measurements
A new method for weighing proteins at the atom level, called individual ion mass spectrometry, has been developed by American researchers.
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3D models developed by researchers to optimise protein design
A computational programme has been created by researchers to aid in the design of proteins for therapeutics, to predict interactions.
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Coronavirus update: recent developments in vaccine research
Drug Target Review’s round-up of the latest developments in 2019 novel coronavirus (COVID-19 or SARS-CoV-2) therapeutics and vaccines.
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WDR74 protein identified as lung cancer and melanoma therapeutic target
Researchers have revealed that the WDR74 protein plays a key role in lung cancer and melanoma, including metastasis, indicating it may be a potential drug target.
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The fate of cancer is all down to particular proteins
Scientists in Japan have identified an important protein that can impact the course of cancer and its fate in the human body.
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Study identifies brain stiffness as crucial for neurogenesis
A research team has shown that a key difference between neurogenic and non-neurogenic tissues is cross-linking proteins causing stiffness, a discovery that could be used to create new brain injury therapies.
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New potential targeted therapy strategy for triple negative breast cancer
A study has shown that targeting the proteins mtp53 and PARP in triple negative breast cancer could inhibit tumour growth and provide a new treatment option.