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How do cells control the secretion of mucin and insulin?
Spanish researchers looking at two crucial proteins uncover how cells release mucin and insulin, leading to new methods to reset deregulation.
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Proteomics
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Application note: How to improve glycoform and glycopeptide coverage for mucin preparations
Here we explore using a mucin-selective protease for tryptic-digest sample preparation of two mucin proteins and assess its potential to improve detecting glycoforms and glycopeptides.
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New insights into influenza A’s infiltration of host cells
US researchers have made a significant breakthrough in understanding how the influenza A virus takes over host cells while minimising damage to itself. By studying the protein PA-X, they found that the virus uses a surgical strike approach, selectively degrading host cell RNA while preserving its own replication, shedding light…
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Ancient virus holds connections to ALS in people
US study identifies promising new target, in protein remnants from an ancient virus, for treating underlying cause of ALS.
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New treatment options for chronic kidney disease
Fresh insights from University of Edinburgh into a protein that causes damage in kidneys and hearts could open up new treatment options for chronic kidney disease.
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Targeting the immunotherapy potential of cytokines IL-12 and IL-18 with new advancements in protein engineering
In this article Dr Raymond Winquist, Oncology Fellow at Alkermes, covers the longstanding research challenges associated with cytokines: IL-12 and IL-18, and their untapped potential in immunotherapy and immuno-oncology.
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Diagnosing inflammatory diseases with synthetic peptides
Researchers from Switzerland identify peptides that detect and measure a key biomarker in inflammatory conditions.
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Diverse senescent cell populations uncovered by single-cell RNA sequencing
Single-cell transcriptomic RNA sequencing analysis has allowed US researchers to identify the specific populations and the dynamic transition states during senescence initiation and progression.
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New technique enables in vivo analysis of protein complexes
Chinese researchers use a glycosidic-bond-based mass-spectrometry-cleavable cross-linker to analyse proteins in vivo.
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Computational tool gets more out of multi-omics data
US researchers developed a next-generation computational tool called NetBID2 that can uncover difficult-to-identify proteins that drive biological processes contributing to cancer.
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Application note: Single Cell Deposition Efficiency
Comparison of single cell dispensing efficiency between Namocell Single Cell Dispenser and limiting dilution method.
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Preventing diet-induced obesity in mice
Japanese researchers discover the mechanism of inhibition of diet-induced obesity in mice by the glucose-dependent insulinotropic polypeptide
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Guide: Tips for Single Cell Isolation
Single cell isolation is a critical step for a number of workflows, and can greatly impact the success of downstream applications.
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Novel peptide may tackle the root cause of type 2 diabetes
British researchers uncover peptide: PEPITEM that could reduce the risk of type 2 diabetes and other obesity-related conditions.
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Application note: Generating clonal GFP cell lines
Namocell single cell dispensers use gentle sorting pressure to isolate and dispense GFP-positive cells into 96-well plates.