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Researchers develop technique to map protein-drug interactions
A new method of melting proteins has allowed researchers to identify new potential drug targets by revealing protein-drug interactions.
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Proteomics
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New route identified for tackling drug resistance in skin cancer cells
A new therapeutic route for combatting treatment-resistant cancer has been identified with the discovery that melanoma cells fight anti-cancer drugs by changing their internal skeleton.
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Deep learning network used to model protein complexes
A new study has developed a deep learning approach that analyses protein interactions, which could improve the design of drugs in the future.
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Antibody characterisation – an essential researchers’ resource
Central to reproducibility in biomedical research is the ability to use well-characterised and defined reagents. The CPTAC Antibody Portal serves as a National Cancer Institute community resource that provides access to many standardised renewable affinity reagents to cancer-associated targets and accompanying characterisation data. Nikki Withers spoke to Dr Tara Hiltke…
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Newly-discovered protein could play key role in fighting obesity
An unexpected finding about a protein that's highly expressed in fat tissue could lead to new approaches for addressing obesity and many other diseases.
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Protein decoy hinders progress of lung cancer growth in mice
Researchers have slowed the spread of a type of non-small cell lung cancer in mice by neutralising a protein that would otherwise cause tumour growth.
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Function of protein involved in liver cancer discovered
The involvement of clathrin in the development of liver cancer has been described for the first time, which could lead to more targeted therapy.
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Proteomic approach reveals metastatic melanoma resistance to therapies
A study has used a proteomic method to uncover why some melanoma tumours do not respond to immunotherapy, which could improve treatments.
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Researchers identify pancreatic cancer protein drug target
A protein that causes pancreatic ductal adenocarcinoma has been identified as a therapeutic target by researchers.
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Key pathway discovered in periodontal ligament maturation
A research team have found a signalling pathway which plays a critical role in the maturation of periodontal ligament, providing information for the development of dental treatments.
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‘Ubiquitin clipping’ proteomics technique could be used as novel treatment
A new technique called ‘ubiquitin clipping’ has been created which could aid proteomics research and the development of new drugs for ubiquitination.
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Machine-learning model to analyse protein sequences
A machine-learning model has been developed to analyse protein sequences, giving an insight to their structure, function and phylogeny...
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FGL2 protein may be an effective target for GBM
Researchers have discovered an immune regulator that appears to dictate glioblastoma progression by shutting down immune surveillance...
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Molecules associated with NMDAR may be involved in schizophrenia
Genetic variants which prevent a neurotransmitter receptor from working properly have been implicated in the development of schizophrenia...
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Scientists developed a new mouse model of Hirschsprung’s disease
Researchers have developed the first viable mouse model of Hirschsprung’s disease and associated enterocolitis with a defect in GDNF/GFRa1/RET signalling...