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Scientists developed a new mouse model of Hirschsprung’s disease

17 January 2019 | By Drug Target Review

Researchers have developed the first viable mouse model of Hirschsprung’s disease and associated enterocolitis with a defect in GDNF/GFRa1/RET signalling...

news

Computational advances in the label-free quantification of cancer proteomics data

1 January 2019 | By Drug Target Review

Proteomics research has become a popular method for characterising functional proteins as well as discovering the innovative targets for oncologic disorders...

article

Proteomics: cracking the molecular mystery of diseases and therapeutics

10 December 2018 | By Anowarul Amin

In the wake of the human genome project, molecular biology and genetic technologies are tremendously integrating into biomedical research. Currently, PCR, qPCR, and sequencing are key tools in the clinical laboratory for the detection and characterisation of microorganisms and genetic disorders.

article

Omics-informed drug target discovery in combating emerging infectious diseases

7 December 2018 | By Pushpanathan Muthuirulan

The catastrophic consequences of ever-increasing rates of death from infectious diseases demands new experimental strategies for drug target selection and drug design. Over the last decade, the pharmaceutical industry has been wounded by several issues including failure of drug-development programmes, burgeoning cost of drug development, increasing regulatory control, lack of…

news

Oral squamous cell carcinoma prognostic signature identified

6 December 2018 | By Drug Target Review

Discovery based on analysis of tissue and saliva samples from oral cancer patients shows a correlation between a signature comprising three peptides and the presence of lymph node metastasis...

article

Drug Target Review – Issue 4 2018

26 November 2018 | By Drug Target Review

In this issue: Omics-informed drug target discovery in combating emerging infectious diseases, measuring intracellular ATP levels to access compound-mediated cellular toxicity, and turning organoids into physiologically relevant high-content assays for drug discovery.

news

Scientists pinpoint mechanism by which mutant p53 protein promotes cancer

7 November 2018 | By Drug Target Review

Scientists in Australia have discovered how the most important gene in preventing cancer, TP53, is hampered in its tumour-fighting efforts by mutant p53 proteins.

news

Atg2 tethers pre-autophagosomal membranes to endoplasmic reticulum

23 October 2018 | By Iqra Farooq (Drug Target Review)

Researchers at Tokyo University have investigated the role of the Atg2 protein in the process of autophagy to aid drug discovery into neurodegeneration...

news

Single molecule fluorosequencing to transform biological research

22 October 2018 | By Iqra Farooq (Drug Target Review)

Single molecule fluorosequencing could revolutionise the way researchers analyse disease, with the method enabling the investigation of single cells...

article

Mass spectrometry and drug development – how the two come together

22 September 2018 | By Manfred Raida (National University of Singapore)

Since the development of the so-called soft ionisation techniques: electrospray ionisation and matrix-assisted laser desorption and ionisation in the 1980s and early 1990s and the development of high-resolution mass spectrometers, mass spectrometry (MS) has come to the fore in studying complex biological systems...

news

Promising new vaccine developed for vivax malaria

20 September 2018 | By Drug Target Review

A study indicates the possibility of using tiny vesicles derived from human immature red blood cell as a vaccine platform...

news

Parkinson’s disease: An endogenous protein might become a candidate for drug development

31 August 2018 | By Drug Target Review

Researchers have deployed a bacterial import signal in order to deliver Nurr1 into cells...

news

Potential drug to cure ciliopathies

30 August 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified a potential treatment that will be a foundation for developing drugs for various genetic disorders...

news

TLR5 protein holds potential for new Alzheimer’s biotherapy

29 August 2018 | By Drug Target Review

Researchers at the University of Florida have discovered that a modified version of an important immune cell protein, TLR5, could be used to treat Alzheimer's disease.

news

Discovery of markers that predict evolution of triple-negative breast cancer

29 August 2018 | By Drug Target Review

Researchers in Spain have identified a means of classifying patients with the most aggressive form of breast cancer - triple negative breast cancer; providing meaningful prognosis for the first time.

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Proteomics