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Proteomics

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New “atlas” charts how antibodies attack COVID-19 Spike variants

26 July 2021 | By Anna Begley (Drug Target Review)

A new “atlas” has been created in the US that charts how 152 different antibodies attack the SARS-CoV-2 Spike protein.

article

Recognition of phosphohistidine-containing peptides by antibodies

16 July 2021 | By Dr Rajasree Kalagiri (Salk Institute), Professor Tony Hunter (Salk Institute)

In this article, Dr Rajasree Kalagiri explains research into the use of monoclonal antibodies for the differential recognition of phosphohistidine-containing peptides.

whitepaper

Application note: High-throughput IgG quantitation platform for clone screening during drug discovery and development

14 July 2021 | By Molecular Devices

Every manufacturing process for potential biologics begins with cell line development, whether it’s for clinical trials or a market launch.

article

How engineered RNA binding proteins delivered in vivo by gene therapy could treat myotonic dystrophy

13 July 2021 | By Dr Jim Burns (Locanabio)

In this article, Dr Jim Burns discusses promising pre-clinical results of how a new platform could treat the root cause of many devastating genetic diseases including myotonic dystrophy type 1.

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Anticoagulant drug a possible strategy to treat COVID-19 variants

8 July 2021 | By Anna Begley (Drug Target Review)

Researchers in Australia have discovered a new site on the COVID-19 Spike protein that could be targeted by an anticoagulant drug.

news

Protein activation discovery could widen access to cancer immunotherapy

8 July 2021 | By Anna Begley (Drug Target Review)

The activation of the protein p53 was shown to boost immune responses against cancer tumours in mice in a new study, potentially widening access to immunotherapy.

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Infographic: Top reasons to select Bethyl bulk antibodies

7 July 2021 | By Bethyl Laboratories

10 reasons to choose Bethyl antibodies and reagents from Fortis Life Sciences for your applications.

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ebook: Optimise your high value cell lines

30 June 2021 | By Molecular Devices

As interest in biotherapeutic proteins grows, the need to reduce cell line development costs and the time to market is more critical than ever.

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Guide: Eight tips for ensuring a successful ELISA

28 June 2021 | By Bethyl Laboratories

Learn quick technical tips to optimise your ELISA workflow, including how to: select the right ELISA kit, avoid contamination and normalise data.

news

Structural changes in SARS-CoV-2 Alpha and Beta variants revealed

28 June 2021 | By Victoria Rees (Drug Target Review)

A study has uncovered previously unknown properties of the Spike protein from the SARS-CoV-2 Alpha and Beta variants.

news

New technique developed for identifying therapeutic nanobodies

25 June 2021 | By Victoria Rees (Drug Target Review)

Researchers have used a new method for discovering nanobodies to identify potential therapeutics against SARS-CoV-2 infection.

news

Dual antibodies effective against SARS-CoV-2 variants in animal study

22 June 2021 | By Victoria Rees (Drug Target Review)

In mice and hamsters, therapies made from two antibodies were found to be mostly effective against a range of SARS-CoV-2 variants.

article

Covalent fragment screening in cell-based phenotypic models of disease: a collaborative approach

22 June 2021 | By Dr Andrew Powell (GlaxoSmithKline), Dr David House (GlaxoSmithKline), Dr Jacob Bush (GlaxoSmithKline), Dr Katrin Rittinger (The Francis Crick Institute), Dr Simon Boulton (The Francis Crick Institute)

The application of chemical perturbation approaches in phenotypic models is often used to identify protein targets for therapeutic discovery. Increasingly, small molecule fragments which covalently bind to their protein targets are being used to explore the druggable proteome and the resulting fragment‑protein interactions are characterised by chemoproteomic techniques. In this…

article

Screening for COVID-19 drugs

22 June 2021 | By Professor Arvind Patel (University of Glasgow)

With the COVID-19 pandemic ongoing, new therapeutic drugs to combat SARS-CoV-2 are still required. In this article, Professor Arvind Patel from the Medical Research Council (MRC) – Centre for Virus Research (CVR) at the University of Glasgow spoke with Drug Target Review’s Victoria Rees to discuss the work being done…

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Better therapeutic antibodies by design

21 June 2021 | By Aparajita Dubey (CRAMbridge)

The binding specificity and high binding affinity of therapeutic antibodies makes them an ideal therapy for treating a wide range of human disorders. Advancements in antibody technologies have resulted in huge development success along with a boost in novel and improved treatment strategies. However, specific challenges and considerations are faced…

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Proteomics