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Regenerative Medicine

news

GPNMB: a potential therapeutic agent for cardiovascular disease

25 October 2024 | By Drug Target Review

Researchers reveal that GPNMB could be an effective therapeutic agent to improve cardiac function and prevent heart failure.

news

Using microgravity to address limitations of tissue engineering techniques

24 October 2024 | By Drug Target Review

The self-assembly of human liver tissues in low Earth orbit could improve their differentiation and functionality.

news

Damaged small intestine repaired with hPSC-derived organoids

17 September 2024 | By Drug Target Review

Cincinnati Children’s have repaired damaged intestines in a rodent model, moving research efforts closer to clinical trials.

article

Macrophage cell therapy: a new hope for chronic liver disease patients

28 August 2024 | By Cliff Brass (Resolution Therapeutics)

Resolution Therapeutics is pioneering a novel approach to the treatment of chronic liver disease – by engineering the patient’s own macrophages to include regenerative properties. Cliff Brass, Chief Medical Officer at Resolution Therapeutics, explains how the aim is to reduce inflammation, improve liver function, and ultimately eliminate the need for…

news

How 3D tissue shapes emerge in animal development

14 August 2024 | By Drug Target Review

Researchers showed that internal stress, induced by active cell behaviours, shapes the Drosophila wing disc pouch during eversion.

news

Promising new bioactive material to regenerate cartilage

6 August 2024 | By Drug Target Review

A biomaterial that improved hyaline cartilage repair could be used to avoid knee replacements and treat injuries and degenerative diseases.

podcasts

Small molecules for regenerative medicine

20 June 2024 | By Drug Target Review

In this episode, we discuss how new insights into stem cell biology are leading to novel therapeutics in regenerative medicine beyond cell therapy.

news

New method to predict effectiveness of MSCs for cartilage repair in vitro

29 May 2024 | By Drug Target Review

Topological defects in mesenchymal stromal cell self-assembly could suggest their potential for cartilage regeneration.

whitepaper

Poster: Assays for DDX3, DDX5, DDX17, RIG-I, and MDA5

10 May 2024 | By BellBrook Labs

A panel of HTS assays was developed using the Transcreener platform to accelerate the development of selective helicase inhibitors.

whitepaper

Poster: Assays for PRMT5, MLL4, METTL3/14, & NSP14

7 May 2024 | By BellBrook Labs

AptaFluor SAH: A Homogenous, Universal Assay for Histone, RNA, & DNA Methyltransferases. Case Study for PRMT5, MLL4, METTL3/14, & NSP14

news

Accelerating cardiac regenerative therapy with HiPSC spheroids

29 April 2024 | By Drug Target Review

Injections of cardiac spheroids into primate ventricles improved left ventricular ejection after four weeks.

Researcher adjusting a 3D bioprinter to 3D print cells onto an electrode. Biomaterials, tissue engineering concepts.

article

Streamlining the path from lab to market with 3D bioprinting

18 March 2024 | By Dr Vidmantas Šakalys (Vital3D), Ellen Capon (Drug Target Review)

In this Q&A, Dr Vidmantas Šakalys, CEO of Vital3D, provides insights into the potential of 3D bioprinting to revolutionise the traditional drug development process, facilitating more accurate models and limiting the use of animal testing.

news

Novel 3D stem cell therapy to treat critical limb ischaemia

14 March 2024 | By Drug Target Review

Exhibiting an excellent angiogenic effect, the stem cell therapy could provide an alternative to angioplasty procedures.

news

Combatting osteoarthritis with cartilage replacement therapy

1 March 2024 | By Drug Target Review

Limb bud progenitor cells efficiently generated new cartilage in osteoarthritis patients, which could lead to cartilage replacement therapy.

news

Investigating the inflammatory myocardial microenvironment

13 February 2024 | By Drug Target Review

By studying the molecular cell states within transplanted paediatric hearts, researchers have unlocked new treatment strategies.

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Regenerative Medicine