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Induced pluripotent stem cells and CRISPR reversed diabetes in mice
Induced pluripotent stem cells made to produce insulin and CRISPR, used to correct a genetic defect, cured Wolfram syndrome in mice.
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Research & Development
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Lead SARS-CoV-2 inhibitor compound identified by researchers to treat COVID-19
Researchers have found a lead compound which they say inhibits SARS-CoV-2 viral replication and demonstrates good pharmacokinetic activity in vivo.
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Developing immunotherapies for hard-to-treat cancers
Exploring how therapies with multi-faceted approaches could improve options for treatment-refractory cancers, like pancreatic and triple-negative breast cancer.
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Could T-cell immunotherapy be the answer to COVID-19?
Scientists from Singapore have argued that T-cell immunotherapy can be used to combat a range of infectious diseases, including COVID-19.
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Researchers develop open access database on macrolactones
A group of researchers has created a free library of 14,000 known macrolactones for other scientists to use in drug development.
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Novel antibody treatment for OCD demonstrates efficacy in mice
Researchers who administered an antibody to neutralise an OCD-associated protein in mice found it reduced their anxious behaviours.
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Glycomimetics could prevent COVID-19 from infecting human cells
Glycomimetics, a novel class of antivirals, prevented influenza, herpes viruses and papillomaviruses from infecting cells in animal models and could show similar efficacy against COVID-19.
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High-throughput protocol for producing tetramer assay probes used to investigate COVID-19
The developers of a novel method to create immunological assay probes for screening T cells has leveraged their new protocol against COVID-19.
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Binding site of drug compound and tumour suppressor protein revealed
Using cyro-electron microscopy, researchers have imaged the binding site between a molecule and the tumour suppressor protein PP2A, enabling optimisation of the drug compound.
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Chemical tool developed to examine lipids in living cells
A new method has been developed by researchers using chemical tools activated by light to influence lipid concentration in living cells.
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UK government funds 21 new research projects into COVID-19
A total of 21 COVID-19 research projects have been granted funding by the UK government, including vaccine and therapeutic development.
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Novel gene promoters could improve gene therapies for neurological diseases
Novel promoters based on those in the herpes viruses, enabled delivery of larger genes and increased the period they were active in the nervous system.
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Cynomolgus macaques: a promising animal model of COVID-19 infection?
Researchers comparing the effects of SARS-CoV-2, SARS-CoV and MERS-CoV in cynomolgus macaques suggest they could be an effective animal model for testing COVID-19 therapeutics.
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Universal Ebola vaccine shows promise in pre-clinical trials
An Ebola vaccine that has been tested in animals could potentially be used to neutralise four species of the virus, say the researchers.
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Drug compound used to overcome chemotherapy resistance in mice
Researchers testing 2-deoxy-D-glucose in mouse models of ovarian cancer report that the compound significantly improves the effectiveness of the chemotherapy drug, carboplatin.