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Drug compound used to overcome chemotherapy resistance in mice
Researchers testing 2-deoxy-D-glucose in mouse models of ovarian cancer report that the compound significantly improves the effectiveness of the chemotherapy drug, carboplatin.
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Research & Development
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Specialised proteins could halt cytokine storms in COVID-19 patients
Researchers who developed modified proteins say this could be used in the fight against COVID-19, by tackling cytokine storms.
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High-throughput screening for antibody-based drugs
A collaboration between academia and industry has produced an assay and new screening technique which utilises directed evolution for the discovery of antibody-based drugs.
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Consortia of microbes could reduce inflammation and promote colon health, say researchers
A study has shown that two products of bacterial bile metabolism boost the conversion of precursor T cells into peripheral Tregs, which suppress chronic inflammation in the colon.
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Drug could prevent cognitive decline associated with brain tumour radiation
Researchers demonstrated NSPP completely prevented cognitive decline in mice treated with radiation for patient-derived glioblastomas.
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Stem cells in COPD patient lungs revealed as drug target for condition
There are heightened levels of abnormal stem cells in the lungs of COPD patients, presenting a drug target that researchers are screening compounds against.
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Celltrion selects 14 lead monoclonal antibodies for COVID-19 treatment
After screening 300 antibodies, Celltrion has identified the 14 most powerful that could potentially combat the COVID-19 coronavirus.
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The coronavirus as a personalised enemy of mankind
How has evolution led us to the point where humans are an ideal host for SARS-CoV-2, the virus that causes the COVID-19 coronavirus?
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Researchers reveal how remdesivir prevents COVID-19 viral replication
According to a new study, the drug remdesivir is a very potent inhibitor for coronavirus polymerases - demonstrating its potential for combatting COVID-19.
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COVID-19 Drug Repurposing Database made open-access by Excelra
The enterprise revealed that it has made its COVID-19 Drug Repurposing Database open-access to aid in the search for an effective therapeutic.
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Novel 3D imaging technology could improve fluorescence microscopy
A new technique called Coded Light-sheet Array Microscopy (CLAM) has been developed by researchers to improve 3D imaging of living specimens.
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Main COVID-19 protease revealed, enabling screening of potential drugs
Chinese researchers who determined the crystal structure of the COVID-19 protease Mpro used this information to screen over 10,000 compounds to combat the coronavirus.
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Mesenchymal stem cells secretome as a prospective therapeutic option for COVID-19 patients
Researchers propose using mesenchymal stem cells to counter the pro-inflammatory cytokines associated with COVID-19 coronavirus symptoms.
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Disrupting tumour pH levels could be novel strategy to fight pancreatic cancer
By targeting NHE7 transport proteins in pancreatic tumours, researchers caused the pH of cancer cells to become acidic, combatting the condition.
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Refreshing how we approach neuroscience with a novel screening technology
Drug Target Review discusses how NETSseq, a novel profiling technology, is bringing new insights to neurodegenerative and psychiatric diseases.
