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Oligodendrocyte abnormality identified as potential cause of autism
Researchers have revealed that the disruption of oligodendrocytes, which produce myelin, may be a cause of autism spectrum disorder, so presents a therapeutic target.
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Research & Development
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Kidney stem cells isolated from urine could be the future of regenerative therapies
Research into alternative stem cell sources has identified urine derived renal progenitor cells (UdRPCs) as a possible option for use in regenerative kidney therapies in the future.
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C1 compound identified as promising Alzheimer’s drug candidate
Researchers have screened thousands of drugs to discover that C1 effectively blocks the production of amyloid fibrils, so could be an effective therapeutic.
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Influenza B M2 proton channel structure resolved by researchers
Research into the M2 proton channel of influenza B has revealed its structure, which the team hope can aid in the development of targeted therapeutics to block the channel and treat the condition.
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Researchers highlight link between microbiome and melanoma
A study of published papers has revealed the importance of research into how the microbiome affects the development of melanoma.
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Precise features of CAR T cell-resistant cancer have been identified
The mechanism that prevents destruction of cancer cells by CAR T-cell therapy has been identified by researchers in Pennsylvania.
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Novel antiviral material made from sugar developed by researchers
Modified sugar molecules have been developed by researchers as antiviral materials which are non-toxic to humans, according to a new study.
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Putrescine could be a therapy for chronic inflammatory diseases
Research has identified that putrescine, which aids macrophages in clearing dead cells, is lacking in atherosclerosis animal models and could be a potential therapeutic for the condition.
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Autophagy: the key to effective MERS-coronavirus treatment?
A promising route for tackling the often-fatal MERS-coronavirus (MERS-CoV) has been identified by researchers in Germany.
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Body-on-chip technology: resolving current limitations in drug discovery
Researchers have developed a new body-on-chip technology that can demonstrate the pharmacokinetics and pharmacodynamics of drugs in a pre-clinical setting without the need for animal testing.
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Inducing factor transforms pluripotent stem cells into totipotent cells
A study has demonstrated that a totipotency-inducing factor can reprogramme stem cells and induce totipotent-like states, possibly increasing their therapeutic potential.
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Brain cancer model developed to study glioblastoma
Researchers have used stem cells, CRISPR and gene sequencing technology to create the basis of a new brain cancer model that could offer opportunities for drug discovery.
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Inflammatory molecules for controlling capillary loss discovered
Scientists have discovered three major pro-inflammatory mediators that drive capillary loss and identified drug combinations to prevent the degeneration of these tiny blood vessels.
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The growing possibilities for stem cells in pharma
Drug Target Review explores the latest applications of stem cells in modelling disease, drug production and the most recent steps in regenerative medicine provided by research.
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Boris Johnson announces UK Global Talent visa for researchers
Boris Johnson, the Prime Minister of the UK, has announced a new Global Talent visa for researchers and scientists which will fast track those in certain fields.