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Experimental HIV vaccine induces bnAb production in models
Researchers have developed a vaccine for HIV that has shown success in rabbits, by neutralising a wide range of HIV strains using bnAbs.
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Machine learning programme used to predict stem cell growth
Researchers have used machine learning to predict the conditions needed for stem cells to develop a certain way, which could be used to grow 3D organ models.
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Newly-discovered protein could play key role in fighting obesity
An unexpected finding about a protein that's highly expressed in fat tissue could lead to new approaches for addressing obesity and many other diseases.
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Better HIV, lupus and hep C treatments possible with malaria discovery
A new discovery on how the immune system responds to malaria infection could lead to better treatments for hepatitis C, HIV and lupus.
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New molecular drivers of Parkinson’s disease uncovered
Molecular drivers of Parkinson's disease have been revealed by scientists who also determined how they impact the functions of genes involved in the condition and the results may point to potential new treatments.
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ELRIG Drug Discovery 2019: looking back to the future
On 5-6 November, ACC Liverpool hosted the ELRIG Drug Discovery event, which allowed R&D professionals to come together and discuss the latest industry developments.
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Novel metabolic-focused high-throughput screening method developed
Researchers have created a new high-throughput screening system which could identify new drugs by focusing on nucleotide metabolism.
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T-box and tRNA complex structure revealed by study
A team of researchers has uncovered the structure of a T-box regulatory mechanism in bacteria, which could aid in the development of novel antibiotics.
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Self-cannibalising mitochondria discovery may lead to ALS treatment target
A new phenomenon in the brain that could explain the development of early stages of neurodegeneration has been discovered which could lead to a future target for drug therapies for ALS.
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Computational model identifies new candidate cancer genes
A novel computational method has led to the discovery of genes whose alteration may contribute to cancer susceptibility and may lead to new therapeutic targets for cancers.
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Researchers identify antibody that could treat pulmonary arterial hypertension
A study has revealed a new antibody that reverses the effects of pulmonary arterial hypertension in rodents and cell models.
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Dysfunctional B cells found to contribute to age-related metabolic disease
A study has shown that a group of cells called adipose B cells can become dysfunctional with age, causing metabolic conditions such as diabetes, which has provided a drug target.
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A faster and stronger rabies vaccine has been developed
A new rabies vaccine strategy enhanced the speed and magnitude of the anti-rabies antibody responses and could improve the efficacy of currently used vaccines.
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Leukaemia cells can transform into non-cancerous cells
A new discovery that leukaemia type B cells can transform into different cells through epigenetic changes could lead to more effective therapies.
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Phage therapy shows potential to treat alcoholic liver disease
Researchers have discovered that patients with alcoholic hepatitis had high numbers of a destructive gut bacterium and they were able to use a cocktail of phages to target and kill the bacteria, eradicating the disease.