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Antibiotics with novel mechanism of action discovered
A new family of synthetic antibiotics that possess broad anti-Gram-negative antimicrobial activity has been discovered.
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Research & Development
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Fullerene compounds could be effective therapy against NSCLC
Researchers have used fullerene compounds to cause NSCLC cell death in cell and animal models, which exhibited low toxicity for healthy cells.
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Novel therapeutic strategy reverses autism symptoms in mice
Researchers have discovered a pathway that causes behavioural abnormalities and other hallmarks of autism; they also revealed how to silence this and reverse the symptoms in mice.
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Silencing RNA nanotherapy shows promise in treating pancreatic cancer
Peptide-based nanoparticles have been designed which can suppress pancreatic cancer growth without the toxic side effects.
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New way to target treatment-resistant cancers identified
A new mechanism by which cancer cells become resistant to chemotherapy has been found which could lead to a new target for drugs.
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LVNC congenital heart condition linked to faulty signalling pathway
A new study, which has shown that the congenital heart condition LVNC could be be caused by signalling defects, may lead to potential therapies.
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Making tumour cells stiff could prevent cancer metastasis
A study has demonstrated that the stiffness of cells indicates whether a tumour will spread and inducing this state could help to avoid metastasis.
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Researchers create blastocyst-like models from mouse cells
Mouse blastocyst-like structures called blastoids have been developed by a team which could be used to study early developmental diseases.
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Study finds astrocytes critical in progression of Huntington’s disease
The new research shows that astrocytes contribute to Huntington’s disease symptoms, but suppressing a mutation stops the disease from progressing.
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Full gene-replacement model developed for Alzheimer’s MAPT gene research
Researchers in the US have successfully produced a mouse model with a human MAPT gene to enable more accurate research into Alzheimer’s therapy.
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Platform may find new options for mental health treatment
A drug discovery platform for mental health treatment could also help to identify mechanisms for the treatment of substance use disorders.
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Method developed for quicker and simpler production of lipidated proteins
A simple and direct method of introducing lipids into protein has been developed using palladium as a catalyst.
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Mucus has been shown to tame microbes in new study
Glycans, which are found in mucus, have the ability to regulate how microbes behave and could lead to new therapeutics.
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Dementia spreads via connected brain networks, finds study
New findings on dementia reveal that brain atrophy spreads via connected brain networks, rather than simply adjacent areas of the brain.
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Microglia critical for neurodegeneration in mice, study finds
Microglia brain immune cells are vital in conjunction with the APOE4 gene during the development of Alzheimer’s in mouse models, researchers have found.
