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Human cells can write RNA sequences into DNA, study shows
For the first time, scientists have found evidence that polymerase theta can write RNA segments back into DNA.
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New algorithm could make CRISPR gene editing more precise
Researchers have created an algorithm that can predict the efficiencies of guide RNAs for CRISPR, potentially making it more precise.
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Method for high-throughput RNA sequencing in single cells developed
A new method named scifi-RNA-seq marks the RNA of cells with specific barcodes, enabling the sequencing of many cells at the same time.
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RT-ddPCR assay developed to quantify regions of SARS-CoV-2 RNA
Scientists have created a RT-ddPCR assay to analyse both the non-coding and coding RNA regions of SARS-CoV-2.
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SARS-CoV-2 RNA analysis reveals potential treatment targets
Researchers have explored the interaction between SARS-CoV-2 RNA and the host cell, uncovering possible targets to prevent viral replication.
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Potential COVID-19 antiviral formulated with siRNA-nanoparticles
Scientists have created an antiviral therapy using lipid nanoparticles that deliver siRNA to the lungs to treat COVID-19 in mice.
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Single-cell approach generates RNA atlas of breast cancer tissue
Researchers have measured the gene expression of healthy and cancerous single cells from breast tissue, creating an 'RNA atlas'.
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Researchers reveal frameshifting as SARS-CoV-2 drug target
A critical stage of the SARS-CoV-2 replication process, known as frameshifting, could be targeted by new drugs, researchers say.
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Single-cell map of lung cancer sheds light on tumour development
A spatial atlas of early-stage lung cancer has been compiled at single-cell resolution, revealing new therapeutic targets.
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Second mechanism of action discovered for COVID-19 drug remdesivir
Researchers have found that a metabolite of remdesivir potentially targets a SARS-CoV-2 protein involved in suppressing the host cell's defence response.
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Structure of DNA actively involved in genome regulation, study shows
Researchers have shown that topoisomerase TOP2A eliminates negative supercoiling, causing an increase in the number of turns of DNA strands and impacting gene expression.
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Genetic profile of skeleton osteocytes mapped for first time
Researchers have revealed which genes are switched on or off in osteocytes, a bone cell found in the skeleton.
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Novel nanopore platform developed to sequence DNA
Scientists have created a new nanopore sequencing platform that can detect the presence of the nucleobases of DNA.
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New mRNA delivery system effectively protects neurons in rats from ischemia
Researchers have shown that an mRNA delivery system can be used to produce the BDNF protein in rats to protect neurons from ischemia.
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New single-cell transcriptomics method does not put cells under stress
Researchers have created a new single-cell transcriptomics approach that cryopreserves cells, limiting the stress they are put under.