article How engineered RNA binding proteins delivered in vivo by gene therapy could treat myotonic dystrophy 13 July 2021 | By Dr Jim Burns (Locanabio) In this article, Dr Jim Burns discusses promising pre-clinical results of how a new platform could treat the root cause of many devastating genetic diseases including myotonic dystrophy type 1.
news New class of compounds found to block coronavirus reproduction 24 June 2021 | By Victoria Rees (Drug Target Review) In cell cultures, a compound named STM2457 was shown to interfere with coronavirus replication, making it a potential treatment for SARS-CoV-2.
news Novel vaccine against coronaviruses protects mice from infection 23 June 2021 | By Victoria Rees (Drug Target Review) A new mRNA-based vaccine has demonstrated success at protecting against multiple coronaviruses in pre-clinical studies.
whitepaper Application note: Effectiveness of CRISPR‑Cas9 using pools of synthetic crRNAs in high-content analysis screening experiments 21 June 2021 | By Horizon Discovery Chemical synthesis of guide RNAs for CRISPR-Cas9 gene editing enables accurate and rapid production of CRISPR libraries and screening in an arrayed, one-gene-per-well fashion.
news Novel mRNA vaccine provides full protection against malaria in mice 21 June 2021 | By Victoria Rees (Drug Target Review) A new mRNA vaccine based on the malaria circumsporozoite protein was shown to elicit a robust immune response in mice.
news Human cells can write RNA sequences into DNA, study shows 14 June 2021 | By Victoria Rees (Drug Target Review) For the first time, scientists have found evidence that polymerase theta can write RNA segments back into DNA.
news New algorithm could make CRISPR gene editing more precise 11 June 2021 | By Victoria Rees (Drug Target Review) Researchers have created an algorithm that can predict the efficiencies of guide RNAs for CRISPR, potentially making it more precise.
news Method for high-throughput RNA sequencing in single cells developed 2 June 2021 | By Victoria Rees (Drug Target Review) A new method named scifi-RNA-seq marks the RNA of cells with specific barcodes, enabling the sequencing of many cells at the same time.
news RT-ddPCR assay developed to quantify regions of SARS-CoV-2 RNA 2 June 2021 | By Victoria Rees (Drug Target Review) Scientists have created a RT-ddPCR assay to analyse both the non-coding and coding RNA regions of SARS-CoV-2.
news SARS-CoV-2 RNA analysis reveals potential treatment targets 26 May 2021 | By Victoria Rees (Drug Target Review) Researchers have explored the interaction between SARS-CoV-2 RNA and the host cell, uncovering possible targets to prevent viral replication.
news Potential COVID-19 antiviral formulated with siRNA-nanoparticles 19 May 2021 | By Victoria Rees (Drug Target Review) Scientists have created an antiviral therapy using lipid nanoparticles that deliver siRNA to the lungs to treat COVID-19 in mice.
news Single-cell approach generates RNA atlas of breast cancer tissue 17 May 2021 | By Victoria Rees (Drug Target Review) Researchers have measured the gene expression of healthy and cancerous single cells from breast tissue, creating an 'RNA atlas'.
news Researchers reveal frameshifting as SARS-CoV-2 drug target 14 May 2021 | By Victoria Rees (Drug Target Review) A critical stage of the SARS-CoV-2 replication process, known as frameshifting, could be targeted by new drugs, researchers say.
news Single-cell map of lung cancer sheds light on tumour development 11 May 2021 | By Victoria Rees (Drug Target Review) A spatial atlas of early-stage lung cancer has been compiled at single-cell resolution, revealing new therapeutic targets.
news Second mechanism of action discovered for COVID-19 drug remdesivir 11 May 2021 | By Victoria Rees (Drug Target Review) Researchers have found that a metabolite of remdesivir potentially targets a SARS-CoV-2 protein involved in suppressing the host cell's defence response.