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Computational tool gets more out of multi-omics data
US researchers developed a next-generation computational tool called NetBID2 that can uncover difficult-to-identify proteins that drive biological processes contributing to cancer.
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Novel tool helps differentiate between cancerous and healthy cells for AML
Spanish scientists have developed a new method to identify between cancerous and healthy cells for cases of acute myeloid leukaemia (AML).
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Biomarkers show promise for identifying early risk of pancreatic cancer
The finding is an critical first step towards classifying lesions on the pancreas that are at highest risk of becoming cancerous, enabling their removal before they start to spread.
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Researchers find ancient virus genome drives autism
The scientists revealed in mice models that endogenous retrovirus activation increases a foetus’s susceptibility to autism.
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Measles virus can develop mutations that cause fatal SSPE
Japanese researchers find a new mechanism for how the measles virus can cause a rare but fatal neurological disorder: subacute sclerosing panencephalitis (SSPE).
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Host-cell factors involved in COVID-19 infections may predict improved treatments
Researchers have found a potential therapeutic target less vulnerable to potential drug resistance and emerging COVID-19 variants of concern.
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New system for safer CRISPR-based gene drive testing and development
US researchers outline the development of a new system for testing and developing CRISPR-based gene drives in the laboratory, and safely converting them into tools for potential real-world applications.
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New study highlights lipid nanoparticles and mRNA could treat blindness
The researchers developed nanoparticles able to penetrate the neural retina and deliver mRNA to the photoreceptor cells whose proper function makes vision possible.
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Study identifies gene and proteins that could treat dry eye disease
Researchers found that proteins made by stem cells that regenerate the cornea could be new targets for treating dry eye disease.
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Novel protein coordinates melanin production
Japanese researchers reported that a key transcription factor “Nrf3” regulates the process of melanin production in mouse and human cells.
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Five recent cell and gene therapy discoveries
This article highlights five of the latest findings using cell and gene therapy techniques that could be used in the development or design of new therapies.
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Scientists investigate the multi-omic landscape of NAFLD-to-NASH progression
Researchers have presented comprehensive multi-omic profiles to identify genes, non-coding RNAs, proteins, and plasma metabolites involved in NAFLD-to-NASH progression.
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Study in mice shows dietary saturated fats can trigger liver cancer
Japanese researchers showed for the first time processes that are crucial targets for treating liver cancer are enhanced by saturated fatty acid diets.
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Novel gene therapy offers potential treatment for FCMD
Japanese researchers proposed using RNA interference for correcting a mistake in the genetic code of patients with Fukuyama Muscular Dystrophy (FCMD).
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Silencing the messenger in elevated lipoprotein(a)
Elevated lipoprotein(a), or Lp(a), is a major risk factor for cardiovascular disease that affects one in five people worldwide, but currently lacks approved therapies. Here, Dr Giles Campion, EVP, Head of R&D and Chief Medical Officer of Silence Therapeutics, describes the company’s approach to developing an investigational siRNA therapy designed…
