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How ageing triggers Huntington’s disease
A new study found that as patients age, Huntington’s disease gradually impairs the important cellular housekeeping process autophagy, which is responsible for eliminating waste from cells.
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New treatment target discovered for sleep apnoea
A recent study in mice revealed that an ion channel already proven to affect blood pressure in obese mice plays a role in suppressing their breathing, influencing sleep apnoea.
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RNA: the key to cancer research?
In the production of RNA, researchers in Spain and Denmark have found a method for attacking cancer cells.
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Lipid nanoparticle delivery of mRNA could lead to new ‘universal’ COVID-19 treatment
A study has shown that mRNA delivered via lipid nanoparticles blocks multiple variants of SARS-CoV-2 from entering cells in mice.
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Is an HIV vaccine on the horizon?
Researchers in the US have developed a potential HIV vaccine approach that aims to prompt the creation of broadly neutralising antibodies via mRNA.
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New study provides insight for how congenital heart defects manifest
The researchers have found that the cells lining the heart direct the cardiac muscle to grow until the heart reaches its full size.
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Study reveals potential therapeutic targets for pancreatic cancer
Researchers analysed the expression of long non-coding RNAs in samples from patients and tumour cell lines, identifying a group of genes with augmented expression in pancreatic cancer.
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Screening technique could accelerate and improve mRNA therapies
A new single-cell nanoparticle targeting-sequencing approach can measure the cellular uptake of lipid nanoparticles carrying mRNA therapies.
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Broadly neutralising antibody protects Syrian hamsters against Omicron variants
Researchers have found that a broadly neutralising antibody displays strong antiviral activities against Omicron BA.1, BA1.1 and BA.2.
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ELRIG: New modalities in pharmacology and drug discovery
Drug Target Review’s Ria Kakkad recently visited ELRIG and the British Pharmacological Society’s conference on New Modalities in Pharmacology and Drug Discovery which took place in London, UK. This article shares some of the key takeaways from the event.
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Visualising mRNA molecules in the brains of living mice
Scientists have developed a new imaging technique that allows researchers to see gene expression and mRNA molecules in the brains of live mice in real time.
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Scientists discover the key to hepatitis A virus replication
With no current treatments for hepatitis A, scientists have discovered how a protein and enzymes interact to allow hepatitis A virus to replicate.
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New prostate cancer subtype may illuminate treatment strategy
Researchers have identified a previously unrecognised form of hormone therapy-resistant prostate cancer.
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Study shows muscular dystrophies can be repaired with CRISPR-Cas9
Researchers have introduced a CRISPR-Cas9 tool into human muscle stem cells using mRNA, thus discovering a suitable method to treat muscular dystrophies.
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Chemical markers that may unlock future therapeutic uses of messenger RNA
Researchers have found new ways to artificially induce mRNA to respond in ways that could eventually lead to therapeutic outcomes.