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Researchers suggest SKI complex of SARS-CoV-2 as novel drug target
Researchers have discovered new drug compounds that target the SKI complex of SARS-CoV-2, preventing replication.
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Screening
Medical screening is a strategy used to identify the possible presence of an as-yet-undiagnosed disease in individuals without signs or symptoms.
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Developing nanobodies and sybodies to combat COVID-19
Three separate studies have identified nanobodies – a miniature form of antibodies found in camelid species – that can bind to the SARS-CoV-2 Spike (S) protein and neutralise the virus in cells.
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Novel antibody-drug candidate to treat pancreatic cancer developed
Scientists have developed a new antibody-drug conjugate (ADC), made from ICAM1, an antibody that targets pancreatic cancer and the cytotoxic drug DM1 (mertansine).
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T cells facilitate chronic lung injury in the elderly after viral infections, finds study
After viral pneumonia in elderly mice, there is an accumulation of dysfunctional tissue-resident memory T cells in the lungs which scientists suggest may drive chronic inflammation and fibrosis.
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Midbrain organoids developed for automated chemical screening
Researchers have used small molecule neural precursor cells to develop midbrain organoids that enable drug effects to be assessed in a complex cell environment.
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Autoantibodies and over-active neutrophils may be cause of COVID-19 blood clots
According to a new study, blood clots in patients with severe COVID-19 are caused by an autoimmune antibody that circulates in the blood and attacks cells.
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ebook: Phenotypic screening with iPSC-derived cardiomyocytes and neurons
Identify therapeutic effects and adverse responses to compounds earlier in the drug discovery process.
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Webinar: High-content analysis and phenotypic characterisation of 2D and 3D cellular models
Combining 2D and 3D models with live-cell assays allows monitoring of cell responses in real time and provides important insights about compound treatment effects, biological complexity, and physiological relevance of assay results.
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Application note: Phenotypic characterisation of neuroactive compound effects
Learn how to perform complex analysis of calcium oscillations and assess cellular and mitochondrial toxicity.
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Whitepaper: The impact of COVID-19 on neurological systems
Neurological symptoms have been observed in COVID-19 patients. The link between SARS-CoV-2 and the CNS is critical to developing effective treatments
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Video: Gain deeper insights into cellular 3D structures with water immersion objectives
Water immersion objectives are essential for capturing more data at greater depths in 3D structures, such as spheroids and thick tissues.
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Application note: Assess transduction efficiency of CFP-tagged nuclear protein with automated cellular imaging
Evaluating and quantitating nuclear transduction.
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Lead drug candidate identified as potential neuroblastoma treatment
Using hit-to-lead processes, researchers have discovered that KSP inhibitors prevent tumour growth and prolong survival in mice with neuroblastoma.
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Platform for hit-to-lead identification of antibacterial lysins developed
A group of scientists has created a novel high-throughput hit-to-lead development platform to identify engineered antibacterial lysins.
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Hit-to-lead from small molecule library screens can identify new vaccine adjuvants
Researchers have screened small molecule libraries and then applied hit-to-lead approaches to discover effective vaccine adjuvants.