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Blocking bacterial competence could prevent antibiotic resistance
Scientists suggest competence-blocking, ‘anti-evolution’ drugs could be administered alongside antibiotics to prolong the period before bacterial resistance emerges.
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Screening
Medical screening is a strategy used to identify the possible presence of an as-yet-undiagnosed disease in individuals without signs or symptoms.
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Multi-organ-on-a-chip developed for drug toxicity screening
The model was tested on a panel of drugs that are both still on the market or have been recalled due to adverse effects and was able to show their toxicity.
news
Metal-containing compounds could lead to new antibacterials
International collaboration has shown that compounds with metals in them show antibacterial activity against MRSA, E. coli and A. baumannii.
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Coronavirus update: recent developments in vaccine research
Drug Target Review’s round-up of the latest developments in 2019 novel coronavirus (COVID-19 or SARS-CoV-2) therapeutics and vaccines.
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2020: Reset your expectation for surface plasmon resonance (SPR)
25 February 2020 | By Bruker Daltonics
Learn about the latest software tools for Bruker Daltonic’s SPR instrumentation and explore high-throughput screening strategies enabled by their ecosystem.
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Utrophin as a novel therapeutic approach for Duchenne muscular dystrophy
Upregulating utrophin using small molecules could be a new therapeutic approach for Duchenne muscular dystrophy (DMD).
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Novel antibiotic compound revealed through artificial intelligence screening
A new antibiotic compound has been identified by researchers who designed a machine-learning algorithm to screen millions of molecules.
news
Single cancer cells in lab-grown tumours analysed with new technology
New technology is for the first time enabling scientists to analyse the individual behaviour of millions of different cells living inside lab-grown tumours, which could lead to new personalised cancer treatments.
news
High-throughput screening reveals new compound to maintain lung health
Researchers have screened 20,000 molecules to discover a potent compound with low toxicity that restores the balance of healthy stem cells in the lungs of mice.
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Novel molecules to adjust the circadian rhythm
A collaborative team of researchers has discovered two molecules that target the melatonin receptor, responsible for regulating the circadian rhythm. This article delves into their study and its therapeutic relevance for the body clock.
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Novel technique creates complex synthetic drug molecules
A new method has been developed by researchers to create synthetic molecules which replicate natural structures and have potential medicinal uses.
whitepaper
Application note: See what’s really in your formulation with backgrounded membrane imaging
Backgrounded Membrane Imaging (BMI), used by the HORIZON® particle analysis system, performs measurements of subvisible protein aggregates.
whitepaper
Case Study: Optimising upstream bioprocessing in cell line development
Read how Cyto-Mine® has helped improve overall efficiency and productivity in cell line development at FUJIFILM Diosynth Biotechnologies.
whitepaper
ebook: Accelerating antibody discovery
Hybridoma-based antibody discovery: the challenges and how to overcome them using microfluidic picodroplet technology.
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New variant of the GLA gene to be linked with Fabry cardiomyopathy
A study in Finland has found a strong connection between the A143T variant of the GLA gene and increased risk of Fabry cardiomyopathy, which affects the heart, kidneys and nervous system.