Screening

New vaccine protects from widespread, costly infection

14 November 2019 | By Rachael Harper (Drug Target Review)

A new vaccine against the Staphylococcus aureus infection has proven effective in experiments with mice, with an 80 percent survival rate.

Application note: Multiplex Fluorescent Western Blot Detection

13 November 2019 | By Analytik Jena

Challenge: One touch imaging of multiple proteins on the same blot with NIR fluorescent tags. Solution? Automated imaging with the UVP ChemStudio.

eBook: Simple as a Selfie: One-Button Scientific Imaging

13 November 2019 | By Analytik Jena

Proper signal visualization, detection, and quantification are paramount to the acquisition of accurate and reproducible data...

Application note: In Vivo Imaging with GFP

12 November 2019 | By Analytik Jena

Challenge: Non-invasive imaging of a patient-derived orthotropic mouse model of pancreatic cancer expressing GFP. The solution? In vivo imaging.

eBook – Getting the Inside Story: In Vivo Imaging

12 November 2019 | By Analytik Jena

In vivo imaging has been an indispensable and powerful tool in biomedical research, enabling a number of significant breakthrough discoveries.

Analytik Jena

Liver-Chip used to study toxicity of drug candidates

7 November 2019 | By Victoria Rees (Drug Target Review)

Researchers have made a ‘Liver-Chip’ which is able to demonstrate the toxic effects of drug candidates and compounds in human patients.

Application note: Reliable Single Cell Cloning with Advanced Microfluidic Dispensing

24 October 2019 | By Sphere Fluidics Ltd.

Find out how to accelerate and improve selective single cell cloning with advanced microfluidic dispensing.

New horizons in small molecule solubility screening

22 October 2019 | By Halo Labs

Aqueous solubility of small molecule compounds is an essential parameter during the hit-to-lead stage of drug discovery as well as lead optimization and formulation. Low solubility can result in misleading ADMET/DMPK analyses if some fraction of a compound precipitates. Watch on-demand to find out more!

CRISPR RNA-cutting enzyme programmed to kill viruses in human cells

14 October 2019 | By Rachael Harper (Drug Target Review)

Researchers have developed CRISPR-Cas13 enzyme-based technology that can be programmed to both detect and destroy RNA-based viruses in human cells.

The challenges of hit-to-lead in drug discovery

7 October 2019 | By Victoria Rees (Drug Target Review)

A study that identified 12 novel compounds that may prove valuable against new drug targets for leishmaniasis and Chagas disease was not without complication. Here, we discuss the findings but also the challenges the researchers reported in their hit-to-lead study.

Application note: Explore cardiac function by measuring calcium oscillation or contraction patterns

4 October 2019 | By Molecular Devices

Understanding the impact of drugs on the cardiac system early in the development process is critical to improving the safety of drugs getting to market.

Whole genome sequencing could be used to improve cancer treatments

30 September 2019 | By Victoria Rees (Drug Target Review)

Researchers have used whole genome sequencing to analyse breast cancers and reveal which are more responsive to treatments, which could improve the development of oncologic therapies.

High-throughput screening used to discover new class of antibiotics

27 September 2019 | By Victoria Rees (Drug Target Review)

Researchers have used a high-throughput screening method to test over 125,000 molecules and identify a new class of antibiotics.

Application note: Automated imaging of cell viability

27 September 2019 | By Cellular Imaging systems from Thermo Fisher Scientific

Automated fluorescence imaging and quantification of cell viability, with EVOS cell imaging system