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Sequencing

stand of DNA behing a side on view of the human head with the brain highlighted in red

news

Epigenetic marks could be the target of future Alzheimer’s therapies

2 October 2020 | By Hannah Balfour (Drug Target Review)

New findings suggest that late-onset Alzheimer's Disease (AD) is driven by epigenetic changes in the brain.

cartoon of magnifying glasses over covid-19 particles in lungs

news

Why do some patients develop COVID-19 pneumonia?

28 September 2020 | By Hannah Balfour (Drug Target Review)

Scientists reveal that some patients who develop severe COVID-19 symptoms mount ineffective immune responses due to a lack of type I interferons, either through genetic mutation or inactivation by auto-reactive antibodies.

article

Cocaine and the brain: identifying targets for addiction therapies

16 September 2020 | By Hannah Balfour (Drug Target Review)

There are currently no licenced pharmaceuticals to treat cocaine addiction. To overcome this issue, US researchers at the University of Alabama at Birmingham have been exploring how cocaine alters transcription in the nucleus accumbens, a region of the brain implicated in compulsive drug use. Here, Hannah Balfour discusses with Dr…

chromosome on an abstract blue to red gradient background - idea of next-generation sequencing of genomics

article

Powering forward – Genomics England’s COVID-19 response

11 September 2020 | By Nikki Withers (Drug Target Review)

Genomics England has launched a next-generation genomic research platform that will play a key role in the response to COVID-19. It is hoped this research environment will transform how genomic data is made usable for global biopharma and academic scientists, providing world‑class patient data security, while enabling the flexibility required…

article

NGS In-Depth Focus 2020

8 September 2020 | By Drug Target Review

In this NGS In-Depth Focus: how next-generation sequencing (NGS) enables rapid detection of viruses and a novel NGS platform advancing genomics research.

cancer cell next to a DNA strnd, idea of cancer genetic mutations

news

Finding order in the chaos of cancer mutations

2 September 2020 | By Hannah Balfour (Drug Target Review)

Scientists observed that different cancers undergo the same genetic mutations at similar stages of evolution, the findings could become part of an ‘evolutionary rule book’ which would theoretically enable the prediction and prevention of cancer’s next evolutionary move.

news

Largest sequencing study of SARS-CoV-2 presents six separate strains

6 August 2020 | By Victoria Rees (Drug Target Review)

Researchers have sequenced SARS-CoV-2, revealing at least six strains with little variability, useful information for vaccine developers.

news

Complete DNA sequence of the X chromosome revealed

15 July 2020 | By Hannah Balfour (Drug Target Review)

Researchers capitalised on novel sequencing technologies to produce the first end-to-end DNA sequence of the X chromosome.

video

Video: ESHG 2019 conference discussion panel: automated sample preparation

10 June 2020 | By Thermo Fisher Scientfic

A result is only as good as the sample preparation that preceded it.

video

Video: Overview of the KingFisher^TM instruments

10 June 2020 | By Thermo Fisher Scientific

ESHG 2019: Automated sample preparation using magnetic bead technology and KingFisher instruments.

coronavirus particle in the crosshares with 'target locked' written above

news

Computational approach identifies novel COVID-19 vaccine targets

9 June 2020 | By Hannah Balfour (Drug Target Review)

Researchers used computational tools to identify regions of the SARS-CoV-2 virus that could potentially provide a safe and long-term immune response.

whitepaper

Application note: High-throughput pathogen detection using a novel MagMAX kit and OpenArray technology

9 June 2020 | By Thermo Fisher Scientfic

Automated detection and isolation of pathogens for multiple samples types.

video

Video: Isolate Circulating tumor cells using the KingFisher

9 June 2020 | By Thermo Fisher Scientfic

New opportunities for liquid biopsy: At automated workflow for isolating circulating tumor cells using KingFisher instruments.

whitepaper

Application note: Sensitive detection of viral nucleic acids

8 June 2020 | By Thermo Fisher Scientific

A simple and sensitive method for nucleic acid extraction from virus-containing samples, with a range of viral loads.

whitepaper

Application note: Metagenomic analysis of the human microbiome

8 June 2020 | By Thermo Fisher Scientfic

Isolate high-quality, inhibitor-free DNA and RNA from human stool and other sample types suitable for metagenomics sequencing.

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Sequencing