Sequencing

Ten genes revealed to contribute to development of schizophrenia

18 October 2019 | By Victoria Rees (Drug Target Review)

Whole exome sequencing has been used by researchers to reveal 10 genes implicated in the development of schizophrenia.

Whole genome sequencing could be used to improve cancer treatments

30 September 2019 | By Victoria Rees (Drug Target Review)

Researchers have used whole genome sequencing to analyse breast cancers and reveal which are more responsive to treatments, which could improve the development of oncologic therapies.

Next generation sequencing for cancer precision medicine

17 September 2019 | By Aino Palva (University of Helsinki), Lauri Paasonen (UPM Biomedicals), Pekka Ellonen (Helsinki Institute for Life Sciences), Piia Mikkonen (Institute for Molecular Medicine Finland), Vilja Pietiäinen (Institute for Molecular Medicine Finland)

The systematic successful treatment of cancer still eludes us and in an effort to refine this area of targeted medicine, Lauri Paasonen and colleagues explore the potential of using patient-derived cells (PDCs) for devising a personalised treatment strategy for solid tumours.

Hitting the target – utilising recombinant antibodies for viral research

17 September 2019 | By Dr Gary McLean (Imperial College London and London Metropolitan University), Nikki Withers (Drug Target Review)

Having worked in antibody research for over 20 years, Gary McLean has seen how the industry has progressed and understands the potential that antibodies have in the future of medicine. Nikki Withers hears how the focus has shifted from discovery to genetic sequence manipulation and how this can be applied…

Whitepaper: Evaluating the impact of error rate on productivity and cost savings in synthetic DNA fragments

16 September 2019 | By Thermo Fisher Scientific

GeneArt High-Q Strings DNA Fragments versus other suppliers’ products.

Largest genome sequencing project launched in UK

13 September 2019 | By Victoria Rees (Drug Target Review)

The UK Biobank, the world’s largest genetics project, will sequence 500,000 genetic samples, which will be available to researchers everywhere.

Drug Target Review – Issue 3 2019

10 September 2019 | By Drug Target Review

This issue includes an investigation into utilising recombinant antibodies for research, a highlight on protein design using computational methods and an examination of the advances in genomic medicine. Also in the issue are articles on next generation sequencing and upstream bioprocessing. 

ALS pathological mediator identified by researchers

4 September 2019 | By Victoria Rees (Drug Target Review)

A potential target for ALS has been revealed by a study which found the Fos-B gene encouraged axonal branching.

Human digestive tract database available for researchers

3 September 2019 | By Victoria Rees (Drug Target Review)

A team from MIT sequenced bacteria samples from the digestive system which can be accessed by researchers to use in the development of treatments.

Researchers identify potential drug target for depression in primates

15 August 2019 | By Nic Losardo (Drug Target Review)

A study has discovered a molecule key in neuronal growth that could be used as a drug target to treat anxiety-related diseases.

Four cell types discovered in glioblastoma tumours

12 August 2019 | By Victoria Rees (Drug Target Review)

A new study has revealed that glioblastomas contain four different types of cell which the researchers say should be treated separately.

Titian Software Ltd

Video: Ethical and regulatory use of biospecimens in the EU

1 July 2019 | By BioIVT

Unique considerations surrounding the bureaucracy and oversight in the use of human biospecimens in the European Union.

Video: Multiplex IHC and digital analysis for immuno-oncology

1 July 2019 | By BioIVT

High content data derived for complex immuno-oncology research facilitates a deeper understanding of the tissue microenvironment.

Strep A vaccine target identified for global use

30 May 2019 | By Victoria Rees (Drug Target Review)

Researchers use high-throughput DNA sequencing technology to identify a potential vaccine target for Strep A.