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Researchers create blastocyst-like models from mouse cells
Mouse blastocyst-like structures called blastoids have been developed by a team which could be used to study early developmental diseases.
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Stem Cells
Stem cells are undifferentiated biological cells that can differentiate into specialised cells and can divide to produce more stem cells.
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Protein responsible for muscle degeneration identified
A study has demonstrated that a certain protein is critical in the decline of muscle regeneration, with the researchers also showing how to inhibit this process in mice.
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Application note: Automated imaging of cell viability
Automated fluorescence imaging and quantification of cell viability, with EVOS cell imaging system
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Application note: High-throughput imaging and analysis of spheroids
High-throughput fluorescence imaging and analysis of spheroids - tips, tricks, and tools to efficiently grow, stain, image, and analyze 3D cell cultures
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New study shows insight into how cells maintain their identity
A new study shows the ways in which epigenetic mechanisms control the activity of genes and may have an impact on the future treatment of certain cancers.
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CRISPR used to treat Duchenne muscular dystrophy in mice
A study has shown that CRISPR can be used as a regenerative technique to treat Duchenne muscular dystrophy, which could be developed as a therapeutic option for humans.
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The elegant parallel of using CRISPR to understand disease mechanisms
CRISPR is the buzzword of the moment in the drug discovery industry – mainly due to its potential to correct disease-causing mutations. However, those using the technology need to be mindful that it is used responsibly, and possible risks are considered before use. Mark Behlke discusses the potential of CRISPR…
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Transplanted brain stem cells survive without anti-rejection drugs in mice
An experiment with mice has successively blocked the immune system's T cells from killing transplanted cells.
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Application note: Multiplexed automated imaging assay for cardiotoxic compounds using the ImageXpress Pico system
There is an increasing need to expand the variety and complexity of cell-based assays for biologic research and drug discovery.
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Nervous system discovery overturns previous theory
A ground-breaking nervous system discovery could be significant for the treatment of different neurological diseases.
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Schizophrenia gene regulator identified by study
Using both computational models and stem cell-based experiments, researchers have identified a gene regulator of schizophrenia.
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Upstream Bioprocessing In-Depth Focus 2019
This In-Depth Focus features articles highlighting the importance of effective data management strategies as well as the recent trends in upstream bioprocessing.
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ALS pathological mediator identified by researchers
A potential target for ALS has been revealed by a study which found the Fos-B gene encouraged axonal branching.
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Pancreas-on-a-chip technology to aid in diabetes research
Scientists combine organ-on-a-chip and stem-cell technologies to make a powerful tool for diabetes research.
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What are the pros and cons of using organoids?
Dr Shona Lang investigates the advantages and disadvantages of using organoids within R&D, highlighting the most important questions to ask before using these models.