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CRISPR technology may improve accuracy of predicting heart disease risk
Scientists may now be able to predict whether carrying a specific genetic variant increases a person's risk for disease using gene editing and stem cell technologies...
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Stem Cells
Stem cells are undifferentiated biological cells that can differentiate into specialised cells and can divide to produce more stem cells.
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Expert view: It’s an exciting time for the use of stem cells in research and the treatment of human disease
The Nobel Prize-winning observations and discoveries of John B. Gurdon and Shinya Yamanaka have ignited an explosion of excitement around the potential use of stem cells in research and treatment of human disease.
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ISSCR 2018 to highlight research driving new discoveries and advances in regenerative medicine
Progress in stem cell research and its translation to medicine is the focus of the International Society for Stem Cell Research annual meeting 20-23 June at the Melbourne Convention & Exhibition Centre in Melbourne, Australia.
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Automated assessment of liver and cardiac toxicities in lead optimisation
This webinar, supported by Tecan, focused on the automated assessment of liver and cardiac toxicities in lead optimisation, using biochemical and human iPS cell assays.
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Expert view: Overcoming the problems of working with human primary hepatocytes
Human primary hepatocytes (hpheps) are the gold standard for in vitro evaluation of drug metabolism, drug-drug interactions, and metabolic disease research. However, hpheps don’t survive in standard 2D culture for very long – no longer than two or three days.
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Application note: Cellartis® Power™ Primary HEP Medium – extend functionality of your primary hepatocytes to 4 weeks
Human primary hepatocytes (hphep cells) are the gold standard for in vitro evaluation of drug metabolism, drug-drug interactions, safety assessment of drug candidates, and disease modeling.
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The role of biomaterials in stem cell-based regenerative medicine
Despite their vast therapeutic potential in such areas as cell therapy and tissue engineering, stem cells have yet to live up to their original hype and demonstrate widespread clinical success.
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Blood stem cells balance the immune system by teamwork
The human body’s blood stem cells produce approximately 10 billion new white blood cells – termed immune cells – every day. Scientists in the U.S. have now discovered that some blood stem cells pick up the slack should any others fail to achieve these levels.
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Stem Cells In-Depth Focus 2018
In this issue: urine-derived stem cells offer an innovative platform for drug testing and disease modelling, a paradigm shift in translational stem cell research, and the role of biomaterials in stem cell-based regenerative medicine.
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Drug Target Review – Issue #2 2018
In this issue: the positive impact of genomics on drug discovery, development and deployment, the confluence of biology and technology, and Artificial Intelligence: harnessing the potential to drive progress in drug discovery promises much for phenotypic drug discovery
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Macrophages support mammary stem cells via chemical signalling
An international team of scientists has discovered that one of the biggest hitters in the immune system, macrophages, provide a cradle for mammary stem cells...
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Elastic microspheres expand understanding of embryonic development and cancer cells
A new technique that uses tiny elastic balls filled with fluorescent nanoparticles aims to expand the understanding of the mechanical forces that exist between cells...
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Scientists overcome cell rejection in neuron replacement treatment for spinal cord injuries
Scientists have successfully overcome the persistent cell rejection that has hitherto plagued attempts to introduce neural stem cells to replace damaged tissue in pigs.
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Cellular reprogramming promotes muscle regeneration in injured mice
Scientists have developed a simple and robust approach for directly reprogramming mature skin cells into immature muscle cells...
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Scientists study long-term effects of stem cell treatment for AICLI
Researchers in China have conducted a unique study investigating the long-term effects of stem cells to treat angiitis-induced critical limb ischemia (AICLI).