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Researchers uncover epigenetic switches that turn stem cells into endothelial cells
26 June 2015 | By Victoria White
UIC Researchers have identified a molecular mechanism that directs embryonic stem cells to mature into endothelial cells...
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Stem Cells
Stem cells are undifferentiated biological cells that can differentiate into specialised cells and can divide to produce more stem cells.
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Researchers grow types of neurons affected by Parkinson’s disease
25 June 2015 | By Victoria White
Researchers have grown the types of neurons affected by Parkinson's disease, starting from neuronal stem cells in a three-dimensional cell culture system...
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Researchers identify stem cell population important in the growth of colon cancer
17 June 2015 | By Victoria White
Researchers at Lawson Health Research Institute have identified a new stem cell population in the colon linked to colon cancer growth...
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Investigation of venom use in stem cell differentiation
Stem cells differentiate to form more than 200 specialised cells, including erythroid bodies, haematopoietic cells, myogenic cells, neural cells, signalling cells and structural cells, such as hepatocytes. Differentiation of stem cells triggers a number of variable changes in the cell, such as membrane potential, responsiveness to signal, metabolic activities, and…
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New compound that represses the PPARy protein could be potential treatment for osteoporosis
12 June 2015 | By Victoria White
Researchers combined a variety of structural biology approaches to rationally design a new compound that could repress the biological activity of PPARy...
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Mini-breast grown in petri-dishes – a new tool for cancer research
12 June 2015 | By Victoria White
Scientists have created 3D organoid-structures that recapitulate normal breast development and function from single patient-derived cells...
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Human pluripotent stem cell-derived cardiomyocytes in drug discovery and development
Procedures for cardiac differentiation of human pluripotent stem cells (hPSCs) have greatly improved over the past few years. The facilitated derivation of hPSC-cardiomyocytes has enabled the thorough assessment of their physiology and manipulation of their properties. Moreover, patient-specific hPSCs generated through cellular reprogramming allow for cardiac disease modelling, discovery of…
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Stem Cells In-Depth Focus 2015
10 June 2015 | By Kenji Schorpp, Kamyar Hadian, Sheraz Gul, Horst Flotow
This Stem Cells In-Depth Focus features articles on stem cell-derived cardiomyocytes, and their use in drug discovery and development, as well as a look at how venom could be used in stem cell differentiation...
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Stem cells discoveries: Arming scientists with the tools they need
10 June 2015 | By Molecular Devices
Molecular Devices discusses stem cells research and the company’s latest technological advancements in this exciting field...
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New anti-cancer stem cell compound in development
7 May 2015 | By Victoria White
Cardiff University scientists have developed a novel anti-cancer stem cell agent capable of targeting aggressive tumour forming cells...
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Scientists identify key receptors behind development of acute myeloid leukaemia
30 April 2015 | By Victoria White
Researchers have found that ITIM - receptors are important to the development of acute myeloid leukaemia (AML), providing a target for potential therapies...
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CiRA and Takeda to collaborate on iPS Cell Research
17 April 2015 | By Victoria White
Takeda and CiRA to work together to develop clinical applications of induced pluripotent stem cells in areas such as diabetes mellitus and immunotherapy...
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The promise of induced pluripotent stem cells for liver disease, toxicology and drug discovery
We discuss the steps required for differentiating human pluripotent stem cells into hepatocyte-like cells, and how long this process takes and the quality control measures needed...
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AstraZeneca to collaborate with the HSCI in search for new diabetes treatments
25 March 2015 | By Victoria White
AstraZeneca to collaborate with the HSCI to adapt a technique that creates human beta cells from stem cells to search for new treatments for diabetes...
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Meet the editorial board members who influenced the Spring 2015 issue
Editor Caroline Richards talks about the editorial board members who have influenced the content coming up in the latest issue of Drug Target Review, available in April 2015...