news
Fibril ‘fuzzy coats’ boost Parkinson’s protein spread
New research reveals that the flexible ‘fuzzy coat’ surrounding α-synuclein fibrils plays a critical role in how Parkinson’s disease spreads between brain cells.
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Structural Biology
article
Advancements in hit identification for membrane protein drug discovery
GPCRs are crucial drug targets, but their complex structures present significant challenges in drug discovery. In this article, Domainex’s Philip Rawlins explores how fragment-based screening and innovative technologies like PoLiPa are helping to overcome these hurdles, with a focus on the Adenosine A2a receptor.
news
CeSPIACE: New peptide drug blocks COVID-19 variants
Scientists have developed CeSPIACE, a peptide drug that offers broad protection against COVID-19 variants, including Omicron XBB.1.5. Find out how it targets a stable part of the virus’s spike protein, making it resistant to mutations.
article
How GPCR agonists, including antibodies, are shaping the future of metabolic care
Find out how Confo Therapeutics is overcoming challenges in GPCR drug development to create next-gen therapies for metabolic diseases.
news
New insights into adhesion GPCRs spark drug design potential
Researchers at the University of Chicago have revealed the complete structure of adhesion GPCRs, uncovering new activation mechanisms that could lead to more targeted drug treatments.
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Cancer Research Horizons collaborates with Diamond to accelerate drug discovery
Cancer Research Horizons has teamed up with Diamond Light Source to drive the discovery of new cancer treatments.
article
Nobel Prize celebrates AI’s role in protein structure innovation
The 2024 Nobel Prize in Chemistry honours AI's transformative impact on protein science, with breakthroughs set to reshape drug development.
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A structural insight into HIV drug-resistance mechanisms
New Salk Institute, US, research could lead to the development of new HIV therapeutics that overcome resistance to existing drugs.
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‘Lava lamp’ vesicles show how cells could self-organise
Looking at how cells can self-organise could help us understand the way cells manage biochemical processes.
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Scientists discover extensive array of protein folds unexplored in nature
A study out of Japan reveals diversity of protein structures and how they fold in nature, uncovering a myriad of protein topologies.
news
New insights on the structural biology of medical cannabis
French researchers underwent a structural study showing that THC cannabinoids inhibit a human enzyme called autotaxin.
news
Snapshots of a mouse brain show OPCs nibbling on neurons
A US researcher studied 3D structures of brain cells and connections, revealing new role for oligodendrocyte precursor cells (OPCs), in mice.
news
Mapped protein structure of Hepatitis C could lead to vaccine
Scripps scientists have mapped the protein structure of the Hepatitis C virus, paving the way for an effective vaccine.
news
Ground-breaking 3D bioprinted tumours aid immunotherapy research
A team of scientists have 3D bioprinted breast cancer tumours and treated them in a new study, offering greater understanding of the disease.
podcasts
Episode 13 – Multiplexing with Dr Luke Gammon, Queen Mary University & Dr David Pointu, Leica Microsystems
Join our experts as they discuss the advantages of multiplexed imaging for a wide range of research and how this technique will develop in the future.
