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Structural Biology

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Structure of DNA actively involved in genome regulation, study shows

10 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that topoisomerase TOP2A eliminates negative supercoiling, causing an increase in the number of turns of DNA strands and impacting gene expression.

Imaging technique for protein that is cancer drug target

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Structure of PLEKHA7 protein domain imaged, presenting cancer drug target

22 April 2021 | By Victoria Rees (Drug Target Review)

A range of imaging and computational techniques were used by researchers to discover the structure of the PH domain of PLEKHA7.

news

Dynamic model of SARS-CoV-2 S protein reveals vaccine targets

7 April 2021 | By Victoria Rees (Drug Target Review)

A model of the SARS-CoV-2 Spike protein surface has uncovered vulnerabilities that researchers say could inform the development of COVID-19 vaccines.

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Revealed structure of enzyme could progress cancer research

5 April 2021 | By Victoria Rees (Drug Target Review)

Researchers have elucidated the 3D structure of the Taspase 1 enzyme, known to be involved in a range of cancers.

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First 3D images of Survival Motor Neuron complex visualised

25 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have imaged the entire Survival Motor Neuron complex using X-ray diffraction analysis, among other techniques.

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Unpredicted binding found between SARS-CoV-2 and hepatitis C drug, telaprevir

24 March 2021 | By Victoria Rees (Drug Target Review)

Insights into the interaction between telaprevir and the SARS-CoV-2 main protease could aid in future COVID-19 drug design, say scientists.

news

Conformational equilibria in GPCRs provides clues about activation

23 March 2021 | By Victoria Rees (Drug Target Review)

Having revealed the activation mechanism and functional states of A2AR signalling, a GPCR, researchers say this could aid drug discovery.

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Molecular technique could provide key for SARS-CoV-2 drug discovery

22 March 2021 | By Victoria Rees (Drug Target Review)

Researchers are using a new method to isolate the complex between SARS-CoV-2 and the ACE2 receptor to keep it embedded in the cell membrane.

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Researchers reveal how key enzyme APT2 works in cells

15 March 2021 | By Victoria Rees (Drug Target Review)

Using X-ray crystallography and simulations, researchers have shown that APT2 is a hybrid between a lipid carrier protein and a hydrolase.

news

Researchers reveal 3D structure responsible for gene expression

12 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have produced the first 3D image of the Mediator-bound pre-initiation complex, key in the regulation of gene expression.

news

SARS-CoV-2 model shows Spike protein co-operation

1 March 2021 | By Victoria Rees (Drug Target Review)

A new coarse-grained model of the complete SARS-CoV-2 virion has revealed potential new ways to combat the coronavirus.

news

Scientists uncover structural biology details of SARS-CoV-2 infection

26 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have used computer simulations to model how the SARS-CoV-2 fusion peptide interacts with and penetrates the cell membrane.

news

New technology enables predictive design of engineered human cells

22 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have developed a computer modelling programme that can produce genetic circuits for cellular engineering.

Coronavirus particles in green with purple extracellular proteins

news

N439K variant of SARS-CoV-2 is resistant to some neutralising antibodies, shows study

1 February 2021 | By Hannah Balfour (Drug Target Review)

The N439K mutation improves the interaction between SARS-CoV-2 Spike protein and the viral receptor ACE2 and eludes antibody-mediated immunity, say investigators.

news

Discovering the mechanisms of antibiotic resistance could lead to better drugs

20 January 2021 | By Hannah Balfour (Drug Target Review)

A single change to the structure of bacterial ribosomes prevents macrolide antibiotics from binding and killing the bacteria, according to a study.

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Structural Biology