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Imaging technique reveals how HIV drugs bind to viral structure
A new study has shown in three dimensions how drugs bind to HIV, which could be used to improve the design of drugs or develop novel therapies.
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Structural Biology
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Researchers suggest IMPDH enzyme could be used to target sleeping sickness
Research into drug targets for sleeping sickness parasite T. brucei has characterised the inosine-5'-monophosphate dehydrogenase (IMPDH) enzyme, providing a possible novel avenue for therapies.
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Membrane protein function behind epilepsy discovered
Researchers have revealed the 3D structure of a membrane protein which plays a role in the development of conditions such as epilepsy and blindness.
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Norovirus structure imaged, providing potential for vaccine development
Researchers have been able to image noroviruses, providing significant information for the development of therapeutics.
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‘Hidden pocket’ could be targeted to treat strokes
Researchers have identified a tiny hidden pocket on the NMDA receptor that could be targeted to treat strokes and seizures...
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Higher radiation tolerance for proteins imaged using LPEM
Liquid-phase electron microscopy could overcome limitations identified through traditional protein imaging techniques and through cro-electron microscopy...
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New tools accurately illuminates intracellular phase separation
Researchers have made discoveries about the formation of cellular components called membraneless organelles and the key role these organelles play in cells...
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Protein adhesion complex cell structure identified
A cell structure identified has given an insight into how cells attach to their surroundings, and could be used to discover potential actions of new drugs...
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Clearest image of Ebola virus protein gained by researchers
Researchers collaborated to identify the clearest image of the Ebola virus protein ever obtained using a cryo-electron microscope...