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CD8+ T cells recognise recent SARS-CoV-2 variants, scientists say
Researchers have revealed that T cells in blood samples from people who recovered from COVID-19 responded to SARS-CoV-2 variants.
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Possible method to apply CAR T-cell therapy to solid tumours developed
Researchers have developed a CAR T-cell engineering technique to ensure that only cancer cells are targeted, leaving healthy cells alone in solid tumours.
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SARS-CoV-2 mutations complicate killer T cell immune response, study shows
Researchers have found that mutations in SARS-CoV-2 T cell epitopes enable the virus to evade the immune response of killer T cells.
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Researchers use viruses as vectors to deliver cancer vaccines
A team has used two viruses to administer specific tumour components in mice with cancer to stimulate their immune system.
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Balanced T-cell response key to asymptomatic COVID-19, study suggests
A new study has suggested that asymptomatic individuals with COVID-19 mount an efficient T-cell response that protects the host.
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Blocking Treg pathway sensitises mice to immunotherapy
Researchers have shown that inhibiting Treg activation in tumours can provide effective immune responses without autoimmune toxicity.
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New COVID-19 vaccine elicits strong protective immunity in mice and monkeys
A new MVA-based vaccine has shown success at inducing COVID-19 antibody and T-cell responses in pre-clinical studies.
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T cells target broad range of SARS-CoV-2 epitopes, study shows
A study has found that T cells combat SARS-CoV-2 by targeting many sites on the coronavirus, not just the Spike protein.
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Biomarker in blood could determine severity of COVID-19
A study has shown that patients with severe COVID-19 have significantly elevated levels of M-MDSCs in their blood compared with healthy individuals.
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CAR T cells targeting the CEACAM7 protein show promise in pancreatic cancer
CAR T cells modified to recognise CEACAM7 were able to eliminate pancreatic ductal adenocarcinoma cells in a late-stage model without toxic effects on healthy tissue.
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Could synNotch CAR T cells be the answer to fighting solid tumours?
Researchers have developed a novel CAR T-cell therapy for neuroblastoma which uses gating to limit toxicity and T-cell exhaustion.
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T-cell exhaustion may limit long-term immunity in COVID-19 patients
Researchers suggest patients who develop mild COVID-19 may not be able to fight reinfection very effectively because their CD8+ T cells show signs of exhaustion.
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A novel CAR T-cell therapy to treat lymphomas
A new form of CAR T-cell therapy has shown promise in mice models to treat blood cancers; this article delves into the development behind the therapy.
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Immune cells discovered in lungs improve flu defence, study shows
A team has found immune cells in the lungs after infection from the flu, which protected mice against reinfection from a different strain.
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Study shows how to improve cancer treatment with anti-OX40 antibodies
New insights into the mechanisms of anti-OX40 antibodies could enable their therapeutic activity to be manipulated to treat different tumours.
