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T cells

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FOXO1 improves survival and function of CAR T cells

12 April 2024 | By Drug Target Review

Evidence indicating that FOXO1 plays a unique role in promoting T cell longevity could result in more effective CAR T cell therapies.

news

Eliminating the HIV virus from infected cells with CRISPR-Cas

20 March 2024 | By Drug Target Review

The proof-of-concept study could lead to a cure for HIV that inactivates diverse strains across multiple cellular contexts.

news

New insights about the influence of STAP-1 on immune cell activation

13 March 2024 | By Drug Target Review

The new findings could lead to a therapeutic target for immune-related disorders, like multiple sclerosis.

news

New insights into PD-1 formation could greatly improve treatments

11 March 2024 | By Drug Target Review

A single change in the amino acid structure of the transmembrane segment can either enhance or diminish the inhibitory function of PD-1 in immune responses.

news

How successive mRNA vaccines shape T-cell memory

11 March 2024 | By Drug Target Review

A new study shows that changes in clonal dominance characterises T-cell memory against multiple COVID-19 variants following mRNA vaccinations.

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article

Gamma delta T cells: a rising star in cancer therapy

28 February 2024 | By Kate Rochlin (IN8bio), William Ho (IN8bio)

Gamma delta (γδ) T cells comprise a distinct and powerful subpopulation of T cells, bridging innate and adaptive immunity, that holds great promise for treating cancer. IN8Bio co-founder and CEO William Ho and COO Kate Rochlin discuss what makes γδ T cells unique, how preclinical research suggests their antitumour activity…

news

New immunological pathway to treat bone tumours

25 January 2024 | By Drug Target Review

Researchers observed significant upregulation of Siglec-15 in the tumour microenvironment in bone tumour samples from breast cancer patients.

news

How PD-1 promotes Merkel cell carcinoma progression

23 January 2024 | By Drug Target Review

Inhibiting mTOR signalling and neutralising mtROS suppressed MCC-PD-1-mediated tumour proliferation in mice.

article

T-cell receptors offer window to the cell for a new class of cancer therapeutics

15 January 2024 | By Daniel Kavanagh (WCG)

Dr Daniel Kavanagh, Senior Scientific Advisor, Gene Therapies, Vaccines and Biologics at WCG, discusses how monoclonal antibodies are limited by their ability to only recognise tumour antigens expressed on the outside surface of a cell. In this article he explains how investigational genetically engineered medicinal products are leveraging T-cell receptors…

news

Changes in CD4+ T cells associated with autoimmune diseases

12 January 2024 | By Drug Target Review

Genetic factors that promote disease development accumulated in CD4+ T cells exhibiting specific gene programmes.

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Article: Tips and Tricks for Leveraging Advanced Flow Cytometry

9 January 2024 | By Sartorius iQue®

Tips and tricks for fully leveraging Advanced Flow Cytometry.

news

Advancing the development of CTLA-4 inhibitors

8 January 2024 | By Drug Target Review

A new study could result in CTLA-4 inhibitors that promote antitumour responses without causing intestinal diseases, such as colitis.

news

HIV vaccine may require a strong response from CD8+ T cells

18 December 2023 | By Drug Target Review

The new findings could help preventive and therapeutic HIV vaccine design and development, and HIV immunotherapy approaches.

news

New contamination-detection test to improve T-cell therapy

28 November 2023 | By Drug Target Review

Method to improve sterility assurance in biopharmaceutic manufacturing will lead to better patient outcomes.

whitepaper

Handbook: Advanced flow cytometry handbook

15 November 2023 | By Sartorius

Don’t miss out on the easier way to do flow cytometry. Learn how to bring speed, throughput, multiplexing and miniaturization, to your bench.

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T cells