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Findings on pancreatic cancer could improve immunotherapies
Researchers have revealed the immune landscape and microbiome of pancreatic cysts as they progress to pancreatic cancer, providing targets for immunotherapy.
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T cells
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New method by which T cells can react to lower doses of antigens
Researchers have discovered a way to ignite T cells, potentially increasing the scope and success of T cell-based immunotherapy.
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Combining immunotherapy and virotherapy shows promise for treatment-resistant cancers
The study describes how oncolytic virotherapy can work with existing immunotherapy techniques, boosting the immune capacity to effectively target and destroy cancer cells.
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How T cells migrate from the tissue to the lymph nodes
Scientists have found that unconventional T cells migrate from tissue into the lymph nodes and influence immune responses there.
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An EGFRvIII-targeted immune-based therapy could potentially treat glioblastoma
A T-cell bispecific antibody shows potent anti-tumour activity in preclinical models of epidermal growth factor receptor variant III (EGFRvIII) mutant glioblastoma.
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Discovered receptor that could alleviate the need for chemotherapy
Researchers have shown that a synthetic IL-9 receptor allows T cells to fight against cancer without the need for chemotherapy or radiation.
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Application note: Advancing CAR T-cell therapy with CTS TrueCut Cas9 Protein
Read this free application note where we look at the CTS TrueCut Cas9 Protein, from its detailed quality specifications to its performance in primary T cells.
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Using immunotherapy to prevent cancer metastases
Scientists have demonstrated how killer T cells used in immunotherapy to eliminate cancer cells can also destroy tumour lymphatic vessels, thus greatly reducing the risk of metastasis.
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New study uncovers the dynamics of adaptive immunity in tuberculosis
A new study has provided insights into how a novel tuberculosis vaccine strategy could work by speeding up the T cell responses in the lungs to shut down infection rapidly.
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Biodegradable gel boosts immune system’s attack on several cancers in mice
A new biodegradable gel can release drugs and special antibodies that simultaneously deplete macrophages from the surgical site and activate T cells.
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Product hub: Drive your drug discovery with an enhanced live cell metabolic assay platform
13 April 2022 | By
Detect rapid, real-time changes in cellular bioenergetics with a platform optimised for pharma.
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Viewing disease through the lens of memory B cells: improving cancer and infectious disease treatment
Looking at disease through a patient’s memory B cells can reveal vulnerabilities within pathogens. In this article, Dr Purnanand Sarma, President and Chief Executive Officer of Immunome, explores how advancements in memory B-cell antibody-based treatments will improve our understanding of how these cells can aid in fighting cancer and other diseases.
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How to develop the next generation of CAR T-cell therapies
CAR T cells have shown incredible promise in the clinic, but there is still room for advancement. One avenue for improvement is through modification of the CAR design. However, given the number of exchangeable domains, testing all variations can present a hurdle. In this article, Dr Sarwish Rafiq, Assistant Professor in…
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Triggering ferroptosis in cancer cells
A new study from the University of Michigan Rogel Cancer Center, US has revealed that a cytokine and a fatty acid can work together to trigger ferroptosis. Here, Dr Weiping Zou, the lead researcher from the study, outlines how this process could be used to target cancer cells and enhance immunotherapies.
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Bulletin: Utilising the multiparameter capability of the Ze5 Cell Analyser to monitor T cell exhaustion and effects of immunotherapy
Read this bulletin to learn about a Bio-Rad study where they developed and tested a 16-parameter flow cytometry panel applicable to the interrogation of a range of biologically relevant markers of T cell activation.
