news Researchers reveal cryo-EM structure of remdesivir bound to SARS-CoV-2 4 May 2020 | By Victoria Rees (Drug Target Review) A group of researchers has used cryo-EM to discover the structure of the remdesivir-bound RNA complex of SARS-CoV-2 and explain how the drug inhibits COVID-19 viral replication.
news Novel antibody treatment for OCD demonstrates efficacy in mice 22 April 2020 | By Victoria Rees (Drug Target Review) Researchers who administered an antibody to neutralise an OCD-associated protein in mice found it reduced their anxious behaviours.
news Software able to screen up to 1.4 billion compounds developed 17 March 2020 | By Hannah Balfour (Drug Target Review) New in silico screening software has the capability to screen billions of compounds, with the hope of improving drug design and limiting side effects.
news Organoid models for personalised treatments of glioblastomas developed 2 January 2020 | By Hannah Balfour (Drug Target Review) Lab-grown brain organoids from patients’ glioblastomas could be useful models to rapidly test and identify effective personalised treatments, find researchers.
news Researchers find 150 possible inhibitors to fight Nipah virus 13 December 2019 | By Victoria Rees (Drug Target Review) A group of scientists from India have used 3D imaging of the Nipah virus to discover potential inhibitors for the disease.
article Hit-To-Lead In-Depth Focus 2019 10 December 2019 | By Drug Target Review This in-depth focus features articles on identifying new leads for neglected tropical diseases and how to develop novel peptide hits into lead compounds.
news Medicine against bone disease found in Saussurea leaves 4 December 2019 | By Rachael Harper (Drug Target Review) Isolated components found in the Saussurea controversa plant have antimicrobial and regenerative properties which could lead to a treatment for bone diseases.
news High-throughput method used to identify cancer drug candidates 25 September 2019 | By Victoria Rees (Drug Target Review) A study using high-throughput screening has revealed some promising compounds that could be used in future cancer treatments.
news Genomic analysis identifies potential prostate cancer targets 14 May 2019 | By Drug Target Review In a recent study more than half of patients with advanced prostate cancers appear to be strong candidates for targeted cancer therapies.
whitepaper Application note: Direct measurements of cellular metabolism for identification of mitochondrial drug targets 29 November 2018 | By Brian P. Dranka, George W. Rogers, Sarah E. Burroughs Drug target identification has a key role in the drug discovery value chain. A critical step in the development of pharmaceuticals is identifying the direct targets of potential drug candidates as well as distinguishing any secondary or off-target effects...
news New technique to simultaneously target fibroblasts while killing cancer cells 19 November 2018 | By Drug Target Review Scientists have equipped a virus that kills carcinoma cells with a protein so it can also target and kill adjacent cells...
whitepaper Whitepaper: A guide to achieving better insight with accurate data 17 July 2018 | By IDBS In today’s modern world, data is everywhere. This eBook will guide you through the steps of how to achieve more with accurate data.
whitepaper Whitepaper: Opportunities in preclinical development 11 July 2018 | By IDBS This whitepaper explains how you can find ways to optimise the holistic preclinical development process...
news New cancer immunotherapy shows promise in early tests 3 July 2018 | By Dr Zara Kassam (Drug Target Review) Researchers report that in preclinical models they can amplify macrophage immune responses against cancer using a self-assembling supramolecule...
news CLR01 protein found in semen increases the spread of Ebola virus infection 26 June 2018 | By Drug Target Review Penn study suggests that targeting amyloid fibrils could prevent sexual transmission...
