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Software able to screen up to 1.4 billion compounds developed
New in silico screening software has the capability to screen billions of compounds, with the hope of improving drug design and limiting side effects.
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Target Validation
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Organoid models for personalised treatments of glioblastomas developed
Lab-grown brain organoids from patients’ glioblastomas could be useful models to rapidly test and identify effective personalised treatments, find researchers.
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Researchers find 150 possible inhibitors to fight Nipah virus
A group of scientists from India have used 3D imaging of the Nipah virus to discover potential inhibitors for the disease.
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Hit-To-Lead In-Depth Focus 2019
This in-depth focus features articles on identifying new leads for neglected tropical diseases and how to develop novel peptide hits into lead compounds.
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Medicine against bone disease found in Saussurea leaves
Isolated components found in the Saussurea controversa plant have antimicrobial and regenerative properties which could lead to a treatment for bone diseases.
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High-throughput method used to identify cancer drug candidates
A study using high-throughput screening has revealed some promising compounds that could be used in future cancer treatments.
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Genomic analysis identifies potential prostate cancer targets
In a recent study more than half of patients with advanced prostate cancers appear to be strong candidates for targeted cancer therapies.
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Application note: Direct measurements of cellular metabolism for identification of mitochondrial drug targets
Drug target identification has a key role in the drug discovery value chain. A critical step in the development of pharmaceuticals is identifying the direct targets of potential drug candidates as well as distinguishing any secondary or off-target effects...
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New technique to simultaneously target fibroblasts while killing cancer cells
Scientists have equipped a virus that kills carcinoma cells with a protein so it can also target and kill adjacent cells...
whitepaper
Whitepaper: A guide to achieving better insight with accurate data
In today’s modern world, data is everywhere. This eBook will guide you through the steps of how to achieve more with accurate data.
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Whitepaper: Opportunities in preclinical development
This whitepaper explains how you can find ways to optimise the holistic preclinical development process...
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New cancer immunotherapy shows promise in early tests
Researchers report that in preclinical models they can amplify macrophage immune responses against cancer using a self-assembling supramolecule...
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CLR01 protein found in semen increases the spread of Ebola virus infection
Penn study suggests that targeting amyloid fibrils could prevent sexual transmission...
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New epigenetic drug against Mantle Cell Lymphoma
A new study presents an epigenetic drug capable of slowing down cell growth in Mantle Cell Lymphoma (MCL)...
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Streamlining drug discovery assays for cancer and cardiovascular disease
For lead optimisation, target-based assays are still the most affordable means of rapidly performing fast iterations and remain core to screening. However, the desire for biological relevance is driving ongoing growth in cell-based assays.