news
DFG €66 million funding for 15 new research training groups
The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is establishing 15 new Research Training Groups to further support early research...
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Target Validation
news
Researchers identify potential Zika Virus target
New research provides insights into why infection with Zika virus after birth generally causes only mild symptoms, whereas devastating foetal malformations can develop when infection occurs during pregnancy.
news
Discovery of ‘mini-brains’ could change understanding of pain medication
The human body’s peripheral nervous system could be capable of interpreting its environment and modulating pain, neuroscientists have established, after successfully studying how rodents reacted to stimulation.
article
Targeting GAS6 in cancer, fibrosis and viral infection
The growth-arrest specific 6 (GAS6) protein has emerged in recent years as an attractive target for drug development primarily because it is the sole ligand for the AXL receptor tyrosine kinase, which plays critical roles in cancer, fibrosis, and viral infection.
news
Researchers find a potential target for anti-Alzheimer treatments
The USP9 gene has an indirect influence on the so-called tau protein, which is believed to play a significant role in the onset of Alzheimer’s disease.
product
ProteinSimple Milo
12 January 2017 | By ProteinSimple
Single-Cell Western system capable of analysing protein expression in ~1,000 single-cells in parallel to unlock heterogeneity...
webinar
New strategy to identify small molecule therapies
1 December 2016 | By Charles River
This webinar details a successful new strategy to identify small molecule therapies to treat protein-destabilizing monogenic disorders...
article
Browsing for drug targets
8 March 2016 | By Edward D. Zanders, PharmaGuide Ltd, Cambridge, UK
Here, Edward D. Zanders explains his motivation behind writing ‘Human Drug Targets a Compendium for Pharmaceutical Discovery’ - a collection of current and potential drug targets mapped to human genes curated by the HGNC...
news
Biogen joins the Centre for Therapeutic Target Validation
8 February 2016 | By Victoria White
Biogen’s new membership follows the launch of the new CTTV Target Validation Platform, which helps researchers identify therapeutic targets for new medicines...
webinar
Genomic support for target selection and validation in drug development: design of a new genotyping array
22 November 2015 | By Illumina
In this webinar, we focus on the use of microarray technology in drug development...
news
GPR3 identified as a new target for Alzheimer’s disease treatment
15 October 2015 | By Victoria White
Researchers have determined that the protein GPR3 might play an important role in alleviating the cognitive deficits of 'amyloid plaques'...
news
Biogen to work with Genomics to refine drug target selection
5 October 2015 | By Victoria White
Biogen will leverage findings from Genomics’ integrated database and analysis tools, which will be used to guide drug research and development...
news
New method of investigating human lung tissue enables improved drug target validation for COPD treatment
30 April 2015 | By Victoria White
Scientists at Helmholtz Zentrum München have succeeded in testing the effectiveness of new approaches for treating COPD on ex vivo 3D-LTCs...
article
Molecular Target Validation in preclinical drug discovery
Preclinical drug target validation has the aim to increase confidence in a particular drug target. The process proves the initial hypothesis that a particular molecular target is key or even causative for pathogenic or symptomatic mechanisms in a disease. Several success factors seem to be of particular importance for the…
