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Helper T cells may hold key to precision allergy treatment
US researchers have connected a rare T cell called Th9 with treating allergies, testing in mouse models with asthma.
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CRISPR and single-cell sequencing highlight genetic variants for traits and diseases
This article highlights a new approach to address human genetics, using STING-seq which provides roadmap to identify variants and genes, enabling deeper understanding of the noncoding genome and targets for therapies
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Reviving T cells to tackle immunotherapy-resistant cancers
US researchers utilise a new approach to immunotherapy, using exhausted T cells that could help overcome treatment resistance in cancers.
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Researchers establish the first human respiratory organoid culture system
A team from the University of Hong Kong has developed the first human respiratory organoid culture system, using it to unveil a novel mechanism for the high transmissibility of the SARS-CoV-2 Omicron variant.
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Genetics behind facial and skull changes in Down Syndrome mouse model
Progress in identifying the gene responsible for facial and skull changes in mouse model of Down Syndrome, made by UK researchers.
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Rhythmic brain activity helps maintain temporary memories
US researchers have discovered that rhythmic brain activity organises the neuronal pathways that maintain short-term memories.
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Light-activated graphene tattoo shows promise in treating heart rhythm disorders
This article outlines the development of the first cardiac implant made from graphene, which is thinner than a single strand of hair yet still functions like a classical pacemaker. It melds softly to the heart to simultaneously sense and treat irregular heartbeats, making it ideal for conforming to soft, dynamic…
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Organ-on-a-chip device aids the study of thrombosis without animal models
Scientists from the University of Birmingham have developed an organ-on-a-chip-model to better understand the mechanisms of deep vein thrombosis.
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Innovative treatment targets blood clots without increased bleeding risk
Safer and more effective blood thinners could be on the way following a ground-breaking discovery by US researchers, that have designed a new compound to target blood clots.
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Revolutionary nanoparticles enable gene-editing in lungs
This article outlines the development of a new type of nanoparticle that can perform gene-editing in the lungs. Scientists from MIT and the University of Massachusetts Medical School have collaborated to create this Ribonucleic acid (RNA) delivery particles, which have the potential to revolutionise the treatment of lung diseases such…
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Researchers develop Raman imaging probes for detecting enzyme activities
Japanese researchers have developed activatable Raman probes based on 9CN-rhodol, offering a promising tool for detecting multiple enzyme activities in heterogeneous biological tissues. This new molecular design strategy allows for highly specific and sensitive detection of enzyme activities, offering potential applications in disease diagnosis and biological research.
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Novel tool helps differentiate between cancerous and healthy cells for AML
Spanish scientists have developed a new method to identify between cancerous and healthy cells for cases of acute myeloid leukaemia (AML).
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New treatment pathway for deadly pancreatic cancers
US scientists have used mouse models of pancreatic cancer to identify genes used by tumour cells to grow uncontrollably.
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Inflammation ‘brake’ gene may impact kidney disease outcomes
Australian researchers uncover a gene that controls inflammation in kidney disease, which could pave the way for more precise disease diagnostics and personalised treatments.
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Recombining drugs helps restore gene’s ability to signal for death of leukaemia cells
US researchers find combination of chloroquine and venetoclax promotes cancer cell death in mouse models with acute myeloid leukaemia (AML).