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news

Novel inhibitor developed to combat HER2-positive breast cancer

26 June 2024 | By Drug Target Review

The inhibitor, HVH-2930, effectively induced apoptosis in breast cancer cells without initiating the heat shock response.

A ribbon model of molecules of protein p53 binding to a strand of DNA. The majority of human cancers involve mutations which make this protein inactive.

news

The potential of deep learning: generating drug targets

25 June 2024 | By Drug Target Review

Researchers have designed synthetic, soluble versions of cell membrane proteins, which will enable faster and easier screening for new drugs.

article

Changing the paradigm of drug discovery processes with AI

25 June 2024 | By Ellen Capon (Drug Target Review), Fabrice Chouraqui (Cellarity)

We had the privilege of speaking to Cellarity’s CEO, Fabrice Chouraqui, about how the company is leveraging AI to completely revolutionise the drug discovery process and unlock treatments for a vast array of diseases, even in the absence of known targets.

news

Mini-colons offer improved cellular diversity, longevity and function

21 June 2024 | By Drug Target Review

Mini-colons, which closely resemble in vivo tissue, were used for several applications, including the characterisation of anticancer drug toxicity profiles.

podcasts

Small molecules for regenerative medicine

20 June 2024 | By Drug Target Review

In this episode, we discuss how new insights into stem cell biology are leading to novel therapeutics in regenerative medicine beyond cell therapy.

news

New AI process for accurate enrolment of patients to clinical trial

20 June 2024 | By Drug Target Review

The AI model screened the medical records of heart failure patients more accurately, quickly and cheaply, compared to study staff.

CRISPR Cas9 protein and DNA molecules, 3D gene therapy rendering

news

Cancer dependencies missed by some CRISPR guides

18 June 2024 | By Drug Target Review

Scientists discovered that, depending on germline variation, CRISPR-based experiments can result in false negatives.

news

Essential insights into HIV-1 latency mechanisms

17 June 2024 | By Drug Target Review

HIV-Tocky, a new viral reporter system, uncovers the molecular mechanisms of provirus silencing and expression.

news

Epigenetic dysregulation mechanism in Crohn’s disease discovered

12 June 2024 | By Drug Target Review

Intestinal epithelial organoids highlight a pathway implicated in CD, named major histocompatibility complex (MHC)-I.

article

eBook: Drop by drop: the future of liquid biopsy

5 June 2024 | By Dr Courtney Noah (BioIVT)

The future of liquid biopsy is poised to revolutionise medical diagnostics and treatment. Explore the latest advancements and future prospects of liquid biopsy in our comprehensive eBook.

Macrophage (white spiky blob) in front of red tissue

news

Macrophage-mediated phagocytosis: treating solid tumours

4 June 2024 | By Drug Target Review

A new immunotherapy approach combining co-engineered T cells and antibodies enhances phagocytosis of tumour cells.

article

The promise of vectors targeting the LDL receptor

4 June 2024 | By Dr Pascaline Lécorché (Vect-Horus), Ellen Capon (Drug Target Review)

In this Q&A, Pascaline Lécorché, Head of Chemical Biology at Vect-Horus, outlines the potential of RNA interference therapeutics and the challenges of their use in vivo. There are several strategies to overcome these, and why peptide-based vectors targeting the LDL receptor are a promising approach.

news

Targeting drug resistance in HER2-positive breast cancer models

30 May 2024 | By Drug Target Review

Researchers discovered that HER2-positive breast cancer drugs must target both HER2 and EGFR receptors to eradicate disease.

podcasts

Exploring the wonders of molecular biology

29 May 2024 | By Drug Target Review

In this episode, we explore our understanding of DNA and its implications for health outcomes. Additionally, we discuss the transition from DNA sequencing to actionable insights in medicine, contrasting genetics-driven drug discovery with traditional methods. Finally, we examine the evolving landscape of genetic technology and its potential impact on the…

news

New method to predict effectiveness of MSCs for cartilage repair in vitro

29 May 2024 | By Drug Target Review

Topological defects in mesenchymal stromal cell self-assembly could suggest their potential for cartilage regeneration.

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