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New study may improve enzyme replacement therapy for Pompe patients
Researchers have developed a new method that could make enzyme replacement therapy more efficient for Pompe disease treatment.
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Targets
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AI method reveals 17 existing drugs that may fight against COVID-19
Scientists used artificial intelligence to identify 17 existing drugs that could kill SARS-CoV-2 in cells, including a dietary supplement.
news
Scientists discover new clue for platelet activation to target thrombosis
Researchers have revealed a novel mechanism for platelet activation, suggesting a potential target for antithrombotic therapy.
article
Getting “under the skin” of frontotemporal dementia
Researchers at the University of East Finland have been using skin cells to investigate pathological hallmarks in frontotemporal dementia patients.
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Mechanisms behind synapse degeneration in Alzheimer’s unveiled
Researchers have uncovered a signalling pathway associated with glutamatergic synapse degeneration in the brains of mice with Alzheimer’s.
whitepaper
Whitepaper: Characterising astroglia models
This whitepaper describes several live-cell phenotypic analyses suitable for the characterisation of astroglia cells.
whitepaper
Info kit: Metabolomics in pharmaceutical research
Accelerate the discovery process of new drugs and targets with a better understanding of the metabolome and lipidome during drug development.
news
New nanotechnology could combat colorectal cancer and melanoma
A nanotherapeutic delivery system displayed high efficacy against metastatic tumours in mice, potentially improving chemotherapy treatments.
news
Obesity could be treated by targeting mitochondrial defect, study finds
Scientists have discovered a new pharmacological approach to reduce the mitochondrial dysfunction that promotes diet-induced obesity in mice.
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Researchers reveal potential cause of COVID-19 aftereffect in children
Scientists have uncovered an important clue to the COVID-19-related multisystem inflammatory syndrome in children (MIS-C).
whitepaper
Application note: High-content phenotypic profiling using the cell painting assay
The cell painting assay uses up to six fluorescent dyes to label and visualize a variety of subcellular structures at the single cell level.
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New research reveals abnormalities in blood vessels of human hearts
A new study has found abnormalities in the blood vessels of human hearts, possibly leading to treatments for cardiac microvascular dysfunction.
whitepaper
Handbook: Latest edition live-cell analysis
The latest edition of the live-cell analysis handbook is a companion guide for live-cell analysis users. Includes discussion of live-cell analysis.
news
Licensed drug may reduce COVID-19 infection by 70 percent
Fenofibrate and its active form, fenofibric acid, have been shown to significantly reduce COVID-19 infection in human cells.
news
Therapeutic target for aggressive cancers discovered through CRISPR
The RNA-modifying protein METTL1 could be targeted to treat some types of aggressive cancers, including brain, blood and kidney.
