news
Pancreatic tumours fooled by glutamine mimic
A novel treatment approach using DON molecule starves tumours of essential nutrient, significantly slowing tumour growth.
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Targets
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AI: age prediction model on human brain tissue developed
For the first time ever, researchers have developed an algorithm to predict age at death and indicate early changes related to disease.
news
Increased pain sensitivity in Neanderthal gene variants
Three gene variants in SCN9A gene, implicated in sensory neurons and inherited from Neanderthals, result in increased pain sensitivity.
news
Neutrophils: vital defence against fungal toxin
New research uncovers how neutrophils trigger cellular processes to counteract the Candida albicans toxin.
news
Vascular cells essential in forming long-term memories
New research reveals capillary cells and neurons work together to ensure memory formation and storage.
article
Stem cell therapy to slow progression of multiple sclerosis (MS)
Autologous haematopoietic stem cell transplantation (aHSCT), a medical procedure typically employed in the treatment of blood cancers, holds promise as a potential therapy for individuals with relapsing-remitting multiple sclerosis (RRMS).
news
Explosive cell death: inflammation-causing gene
WEHI researchers have found that a genetic change of MLKL increases risk of uncontrolled inflammatory response
news
Proteolysis: new method developed to target cancer cells
Researchers have found that targeting chimeras with click-release proteolysis activates specific molecules that target cancer cells without harming health cells.
webinar
Unlocking protein potential: liquid handling solutions for drug discovery
29 September 2023 | By Analytik Jena
Watch this webinar to learn how PROTACs are revolutionising drug discovery, and the critical role protein purification plays in the production of therapeutic proteins.
whitepaper
ebook: Maximizing preclinical confidence in target efficacy and safety
This ebook outlines Euretos’ approach to target discovery and indication expansion. Whilst also discussing data-driven target selection.
news
Advancing obesity and diabetes therapy with brown fat cells
Researchers discover the intricate cellular signalling cues that orchestrate the formation of brown adipocytes in mice.
![In experiments in rats and mice, two Johns Hopkins scientists -- an engineer and an ophthalmologist -- report the successful use of nanoparticles to deliver gene therapy for blinding eye disease. A uniquely engineered large molecule allows researchers to compact large bundles of therapeutic DNA to be delivered into the cells of the eye [credit: John Hopkins Medicine].](https://www.drugtargetreview.com/wp-content/uploads/nanoparticle-gene-therapy-blindness-image.jpg)
article
Possible adulticidal drugs for Onchocerca volvulus
This article discusses the need for adulticidal drugs to treat Onchocerca volvulus infections, a parasite causing onchocerciasis (river blindness), as the current treatment with ivermectin and surgery presents challenges for affected communities. It highlights research findings on the potential of analgesic medicines to target adult worms and emphasises the importance…
news
COVID-19: rapid and reliable detection method
Commercially available mass spectrometers offer a reliable means of detecting the SARS-CoV-2 coronavirus.
article
New research holds significance in regulating T cell function
New research shows T cells use the nuclear receptor RARα not just for gene regulation, but also to trigger cell surface events that activate them against pathogens and cancer.
article
Innovative leukaemia treatment with tcxpress platform
BlueSphere Bio's TCXpress platform revolutionises the isolation and functional characterisation of T-cell receptors (TCRs) with unparalleled speed and efficiency, enabling rapid identification of unique TCRs from thousands of individual T cells within days.