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Connections between nerves and stem cells may be essential for function
Researchers have demonstrated that stem cells attract neurons with different strengths and that connections between the two may be vital for cancer stem cell function.
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Expert view: The path to the high-hanging fruit: access to greater diversity and rapid down-selection
Therapeutic monoclonal antibodies are proven and effective treatment options but many of the ‘low-hanging fruit’ therapeutics have already been identified.
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Lab Automation In-Depth Focus 2020
In this in-depth focus are features on the best data management options currently available and how the future of drug discovery will be connected and fully automated.
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Informatics In-Depth Focus 2020
The articles in this in-depth focus explain how informatics aids in the development of genomic research and outline the next steps for AI to progress in pharma.
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Scientists propose new precise method to measure atoms
A team of Russian scientists has suggested a new method to measure the sizes of atoms as well as their intermolecular interactions, which they say could help drug design.
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High-speed microscope can capture brain signals and calcium concentrations
The novel technology allows researchers to create three-dimensional images of signal propagation and calcium concentration changes in the neocortex of live mice.
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Drug Target Review – Issue 1 2020
This issue includes a spotlight on how genomic assays could revolutionise healthcare, a discussion on how lab automation can improve drug discovery and an analysis of whether antibodies can provide an effective coronavirus treatment. Other article topics in this issue include immuno-oncology and artificial intelligence.
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Novel phage display technique could lead to new peptide-based therapeutics
Researchers have shown that incorporating noncanonical amino acids (ncAAs) in phage display expands the range of peptides it can identify.
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New cancer treatment regimens could be identified with novel technology
A new technology called mass cytometry, or CyTOF, is providing new insights into a range of key proteins in blood cancer cells.
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Novel cryo-EM technology developed using holography
Researchers have created a new cryogenic electron microscopy (cryo-EM) technique by utilising low-energy electrons in a holographic method.
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CRISPR RNA-targeted genetic screen could be used for COVID-19 therapy
A new Cas13 RNA screen has been used to establish guide RNAs for the COVID-19 coronavirus and human RNA segments which could be used in vaccines, therapeutics and diagnostics.
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CRISPR development enables simultaneous gene editing
Using a combination of Cas9 and Cas12a, Canadian researchers have enabled CRISPR methods to edit multiple genes at the same time.
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Inactivated human muscarinic receptors used in new screening method
Researchers have developed a new screening technique by inactivating the molecular structure of the human muscarinic receptor, allowing them to test potential drugs.
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3D visualisation of COVID-19 surface released for researchers
A new 3D model of the surface of the coronavirus COVID-19 has been released, to aid researchers in the development of a treatment.
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New method to probe molecules could improve spectroscopy techniques
Researchers have developed a highly sensitive technique for probing molecules that they say could enable new applications in the fields of spectroscopy.