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Cell-derived therapy may help repair abnormal heart rhythm
A new study has found vesicles secreted from human heart cells may repair damaged tissue and prevent lethal heart rhythm disorders.
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Therapeutics
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VBI Vaccines announces progress from coronavirus programme
Pre-clinical research from VBI Vaccines has demonstrated an encouraging ability to boost and broaden the immune response against the coronavirus Beta variant.
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Simple delivery method that enhances a promising cancer treatment
Scientists have developed a delivery method that enhances treatment by adding CAR T cells and specialising signalling proteins to a hydrogel that is injected next to a tumour.
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Innovative therapy that “tricks” and destroys cancer cells
New research has shown iron-like compound holds promise for treating patients with glioblastoma, an aggressive brain cancer.
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Viewing disease through the lens of memory B cells: improving cancer and infectious disease treatment
Looking at disease through a patient’s memory B cells can reveal vulnerabilities within pathogens. In this article, Dr Purnanand Sarma, President and Chief Executive Officer of Immunome, explores how advancements in memory B-cell antibody-based treatments will improve our understanding of how these cells can aid in fighting cancer and other diseases.
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Neutralising SARS-CoV-2 with intranasally-delivered antibodies
A monoclonal antibody (mAb) developed by IGM Biosciences to combat COVID-19 has shown success in pre-clinical studies and has now moved into Phase I trials. In this Q&A, Dr Chris Takimoto, Chief Medical Officer at IGM Biosciences, explains how this biotherapeutic works to prevent and treat SARS-CoV-2 infection.
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A revolutionary technique to rejuvenate skin cells
Researchers have developed a new method to rewind the age of skin cells by 30 years without losing their specialised functions.
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Research provides a potential drug target to treat diabetes and obesity
A new study by University of Texas Health Science Center at San Antonio has found that boosting liver mRNAs in obese mice reduces appetite and body weight.
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The growth of cell line development
The rising number of biologics approved for therapeutic use has placed an emphasis on safe and efficient production lines. Here, Drug Target Review’s Editor Victoria Rees considers why biotherapeutic development is likely to prompt significant growth for the cell line market in the next decade.
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Gut bacteria may contribute to blood pressure drug resistance
By studying the gut microbes of rats, researchers discovered that a bacteria known as Coprococcus comes contributes to resistance to high blood pressure drugs.
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The promise of mRNA therapeutics in producing the first regenerative treatment for SUI
Dr Roger Dmochowski, Professor of Urology and Associate Surgeon in Chief for Vanderbilt University Medical Center, discusses the promise of potential new regenerative for Stress Urinary Incontinence.
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Potential origins of scleroderma highlighted in new study
Researchers at the Weizmann Institute of Science have shown that fibroblasts may be a factor in the origin of scleroderma.
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Mystery behind odd-shaped blood cancer cells revealed
Researchers have found that the Lamin B1 mutation causes odd-shaped nuclei in blood cancer cells, which may lead to improved care for leukaemia patients.
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Developing modern vaccines against an underrecognised foe
Messenger RNA (mRNA) may be the ‘skeleton key’ that unlocks the door to fight latent viral infections that have plagued researchers for generations. Dr Sandeep Basnet, Director, Clinical Development at Moderna Therapeutics explores modern vaccine development and why mRNA is taking centre stage.
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Are scientists closing in on vaccines for Alzheimer’s and Parkinson’s?
Protecting against conditions that appear in older generations is increasingly becoming a focus of the medical industry. In this article, Dr Andrea Pfeifer, CEO and Director of AC Immune, discusses the current landscape of vaccine development for neurodegenerative diseases such as Alzheimer’s and Parkinson’s.