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Potential target for type 1 diabetes treatment
Researchers have discovered a new pathway to the regeneration of insulin in pancreatic stem cells, findings that could move towards new therapies for type 1 and type 2 diabetes.
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Therapeutics
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Takeda enters agreement with F-star Therapeutics to license bispecific antibody
F-star Therapeutics has announced a licence agreement with Takeda for a novel next-generation immuno-oncology bispecific antibody.
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Scientists discover an antibody that potentially acts as a therapy against SARS-CoV-2
The scientists found that the neutralising monoclonal antibody protected against SARS-CoV-2 infections in animal experiments.
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Using computational modelling to gain insights into flu viruses
Scientists at the University of Pittsburgh have been using computational modelling to understand the body’s immune responses to avian flu.
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How to select the best combination of antibodies to treat HIV
A new computer-based approach could help clinicians select the best combinations of broadly neutralising antibodies to treat HIV based on the virus’ genetics, while minimising the risk of the virus escaping treatment.
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Dominant Omicron subvariants better at evading vaccines and antibody treatments
A new study has found that the latest Omicron subvariants are even better at avoiding vaccines and most antibody treatments than previous variants.
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Soft nickases could be the future of safe, effective gene editing
Researchers in the US have developed a new CRISPR method for treating genetic conditions using nickases that they say is safer and more effective.
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Dissolving implant device relieves pain without drugs
Researchers have created a new implant device has the potential to provide an alternative to opioids and other highly addictive drugs.
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A combination of nanotechnology, chemotherapy and a monoclonal antibody could treat glioblastoma
For the first time, researchers have tested a molecule that combines three distinct technologies against glioblastoma, the most aggressive type of brain cancer.
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Human urine-derived stem cells have robust regenerative potential
A new study provides the possibility to evaluate the capacity of telomerase-positive human urine-derived stem cells to become a wide variety of other cell types.
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New brain mechanism involved in cocaine addiction has been identified
Researchers have found that blocking certain acetylcholine receptors in the lateral habenula made it harder to resist seeking cocaine in a rat model of addiction.
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Using microscopy to understand how bacteria spreads and multiplies
Researchers have been using state-of-the-art microscopy to analyse bacteria’s shapeshifting behaviour, findings which could lead to treatments for UTIs.
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Scientists identify the molecular mechanisms behind learning and memory
Researchers identify how acetylcholine sets off a signal cascade in brain cells that directly influence aversive learning and memory formation. The findings may open door to new therapeutic strategies for Alzheimer’s disease.
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The bigger picture: innovation in microscopy
A broader view of cellular processes during the drug discovery and development stages enabled by microscopy could help scientists to design better therapies for patients. In this interview, Drug Target Review’s Victoria Rees asks Dr Peter O’Toole, Head of Imaging and Cytometry at the University of York, UK about his…
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Novel combination therapy could eliminate colon tumours
Researchers have found that a combination therapy that incorporates a plant virus with an immune cell-activating antibody clears colon cancer in mice.
