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Therapeutics

Treating cancer patients with cancer anorexia-cachexia syndrome

6 January 2022 | By Patrick Kendall (Artelo Biosciences)

In this article, Patrick Kendall, Scientific Advisor for Artelo Biosciences, outlines why future treatment of cancer anorexia-cachexia syndrome may lie with drugs in development offering a mechanistic approach.

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Brain recordings could improve deep brain stimulation therapy for OCD

21 December 2021 | By Anna Begley (Drug Target Review)

Scientists captured more than 1,000 hours of brain recordings from obsessive compulsive disorder (OCD) patients and uncovered candidate neurological signatures.

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Nanotechnology boosts immune response at tumour site in mice

20 December 2021 | By Anna Begley (Drug Target Review)

The new nanotechnology left six of 10 mice with lymphoma tumour-free and was effective in melanoma when combined with existing drugs.

Man's back with kidneys highlighted in orange

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Experimental gel promotes arteriovenous fistula (AVF) formation in rodents

17 December 2021 | By Anna Begley (Drug Target Review)

The self-assembling, nanomatrix gel may represent the first effective therapy to promote healthy arteriovenous fistula (AVF) maturation in kidney disease patients.

Close-up of man's knee with bone highlighted in red

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Common antioxidant reduces osteoarthritis markers in knee cartilage cells

16 December 2021 | By Anna Begley (Drug Target Review)

Gallic acid was found to decrease arthritis inflammation markers and improve the production of desired proteins in arthritic knee cells.

Pills and stethoscope on blackboard with COVID-19 structure written on it

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New platform screens for specific class of coronavirus antiviral compounds

15 December 2021 | By Anna Begley (Drug Target Review)

Researchers developed a platform that can rapidly screen thousands of compounds to identify potential antiviral drugs to treat coronaviruses.

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Researchers investigate gene network to identify “cancer driver genes”

14 December 2021 | By Anna Begley (Drug Target Review)

The new study looked at the network of gene-gene interactions associated with cancer onset and progression to identify therapeutic targets.

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Transformable nanoparticles promise advances in tumour treatments

13 December 2021 | By Anna Begley (Drug Target Review)

A new study provides an in-depth review on the designs and applications of morphology-transformable nanoparticles to improve cancer therapies.

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Experimental enzyme treatment protects mice from lethal anthrax infection

9 December 2021 | By Anna Begley (Drug Target Review)

All mice infected with anthrax spores were completely protected after treatment with a pegylated enzyme known as PEG-CapD-CPS334C.

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Scientists create first patient-specific zebrafish model for ACM

9 December 2021 | By Anna Begley (Drug Target Review)

Researchers developed a patient-specific zebrafish model for arrhythmogenic cardiomyopathy (ACM) and tested istaroxime as a potential therapeutic.

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Targeted nanomedicine reduces vascular lesions in mouse models

7 December 2021 | By Anna Begley (Drug Target Review)

The new nanoparticle uses a peptide to target the vascular cell adhesion molecule 1 and reduced the size of vascular lesions in a mouse study.

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Researchers delineate novel COVID-19 subgroups in critically ill patients

6 December 2021 | By Anna Begley (Drug Target Review)

The new study used sequence clustering analysis to identify four subgroups of COVID-19 to help match patients to specific treatments.

Hand of person with Parkinson's shaking while holding glass of water

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New compound may reduce erratic movements in Parkinson’s patients

2 December 2021 | By Anna Begley (Drug Target Review)

Scientists identify a drug candidate to minimise erratic muscle movements, called dyskinesia, associated with Parkinson’s disease.

Picture of vaccine with "OMICRON" written in background

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Everest Medicines and Providence to develop Omicron vaccine

1 December 2021 | By Anna Begley (Drug Target Review)

Everest Medicines and Providence Therapeutics have started working on a new version of COVID-19 vaccine specifically targeting the new Omicron variant.

Blood test showing positive for COVID-19 Delta variant

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Plant-derived antiviral drug could combat Delta variant

29 November 2021 | By Anna Begley (Drug Target Review)

A novel antiviral drug called thapsigargin (TG) blocked COVID-19 infection in cells, including all new variants, in a pre-clinical study.

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Therapeutics