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Targeted nanomedicine reduces vascular lesions in mouse models
The new nanoparticle uses a peptide to target the vascular cell adhesion molecule 1 and reduced the size of vascular lesions in a mouse study.
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Researchers delineate novel COVID-19 subgroups in critically ill patients
The new study used sequence clustering analysis to identify four subgroups of COVID-19 to help match patients to specific treatments.
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New compound may reduce erratic movements in Parkinson’s patients
Scientists identify a drug candidate to minimise erratic muscle movements, called dyskinesia, associated with Parkinson’s disease.
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Everest Medicines and Providence to develop Omicron vaccine
Everest Medicines and Providence Therapeutics have started working on a new version of COVID-19 vaccine specifically targeting the new Omicron variant.
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Plant-derived antiviral drug could combat Delta variant
A novel antiviral drug called thapsigargin (TG) blocked COVID-19 infection in cells, including all new variants, in a pre-clinical study.
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Prostate cancer organoids pave way towards precision oncology
Scientists develop organoid models of neuroendocrine prostate cancer to study EZH2 inhibitors and reveal a potential new target.
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“Sleeping” cancer cells could prevent tumour metastasis
A new study prevented the growth of metastatic tumours in mice by forcing cancer cells into a dormant state, pointing to novel treatments.
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Single molecule from plant used by Native Americans may treat diarrhoea
Scientists unveil the role of KCNQ2/3 using a functional screen of 40 native US plants and identify nine extracts that could treat diarrhoea.
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Drug intended to treat Alzheimer’s may hold promise for glioblastoma
Verubecestat demonstrated poor results in Alzheimer's trials, but helped suppress tumours in pre-clinical glioblastoma models.
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Rheumatoid arthritis discovery may lead to novel inflammation blockers
A new study links tumour necrosis factor seen in rheumatoid arthritis with T cell dysfunction, potentially leading to new therapies.
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Genetic study could influence the development of COVID-19 therapies
The study is the first in-depth look at links between COVID-19 severity and gene expression in immune cells and may guide future therapies.
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Positive pre-clinical results for CRISPR-based HIV therapy
The CRISPR-based therapy called EBT-101 excised HIV proviral DNA from the genomes of different cells and tissues in human cells and mice.
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Stress hormones linked to Crohn’s disease flare-ups
Removing stress hormones in mouse models restored proper function to immune cells and epithelial cells, pointing to new Crohn's treatments.
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Antihypertensive drugs could treat cerebral small vessel disease
The antihypertensive drug candesartan cilexetil reduced matrisomal protein accumulation in mice with cerebral small vessel disease.
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Antibacterial molecules show promise against antibiotic-resistant bacteria
The new group of molecules can be chemically altered, showing potential for the development of effective antibiotics with few side effects.
