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Therapeutics

Healthy nerve next to nerve with damaged myelin, indicating multiple sclerosis

news

Mechanism discovery provides new model for studying multiple sclerosis

23 September 2021 | By Anna Begley (Drug Target Review)

The over-expression of a growth factor receptor resulted in hypomyelination, leading to diseases such as multiple sclerosis in mouse models.

news

Exosome-based approach reduces levels of HIV in mice

23 September 2021 | By Anna Begley (Drug Target Review)

Scientists have used exosomes to deliver a novel protein that prevented HIV from replicating in the bone marrow, spleen and brain of mouse models.

Person holding hand of Parkinson's disease patient

news

Nasal drugs show promise for slowing Parkinson’s disease

22 September 2021 | By Anna Begley (Drug Target Review)

Two different peptides were found to slow the spread of alpha-synuclein, potentially becoming the first drugs to slow the progression of Parkinson’s disease.

article

Drug Target Review Synthetic Biology ebook 2021

22 September 2021 | By Drug Target Review

In this ebook, discover why CRISPR can aid the development of new drugs via loss-of-function screens and how the field of synthetic biology is likely to evolve within the context of health.

news

Club cell factors may reverse immune suppression in tumours

21 September 2021 | By Anna Begley (Drug Target Review)

New research has revealed that club cells secret anti-immunosuppressive factors in tumours, potentially revolutionising cancer therapies.

news

Eczema may stem from poorly regulated sex hormones, study finds

20 September 2021 | By Anna Begley (Drug Target Review)

A breaking discovery has revealed the gene HSD3B1 that regulates the production of sex hormones is linked to atopic dermatitis (AD).

news

Controlling PTEN gene could combat paediatric rhabdomyosarcoma

20 September 2021 | By Anna Begley (Drug Target Review)

The decreased expression of PTEN in mouse models was found to make rhabdomyosarcoma tumours more aggressive, highlighting new treatment approaches.

news

Scientists create organoid biobank to study SARS-CoV-2 genes

20 September 2021 | By Anna Begley (Drug Target Review)

Researchers have established an organoid biobank to search for genes that are essential for the spreading of SARS-CoV-2 infection.

Staphylococcus Aureus grown in petri dish

news

Ex vivo stem cell treatment a promising therapy against MRSA

17 September 2021 | By Anna Begley (Drug Target Review)

A new ex vivo model treated animal wounds with mesenchymal stromal cells (MSCs) and reduced MRSA infection, expanding therapeutic options for humans.

news

Scientists reveal that glioblastoma shows dependency on biotin distribution

15 September 2021 | By Anna Begley (Drug Target Review)

Researchers discovered that glioblastoma cells rely on biotin distribution for growth, leading to possible future drug combinations.

news

Gut microbiome linked to rheumatoid arthritis prognosis

15 September 2021 | By Anna Begley (Drug Target Review)

New genomic study reveals that the microbiome could predict rheumatoid arthritis prognosis, potentially advancing treatments.

news

Gene therapy for Morquio A disease successful in rat model

14 September 2021 | By Anna Begley (Drug Target Review)

A novel gene therapy has fully corrected whole-body alterations in a rat model, paving the way for Morquio A therapies.

news

Scientists create cellular blueprint of multiple sclerosis lesions

13 September 2021 | By Anna Begley (Drug Target Review)

An NIH team have built a cellular map of chronic multiple sclerosis (MS) lesions to identify cells that drive inflammation and potential therapies.

news

STING-activating drugs could customise cancer treatments

9 September 2021 | By Anna Begley (Drug Target Review)

An imaging technique identified emerging drugs that activate the STING protein to alter metabolic pathway activity in cancer cells.

news

Stem-like T cells could improve immunotherapy treatments

7 September 2021 | By Anna Begley (Drug Target Review)

Targeting stem-like T cells within certain lymph nodes could improve the number of cancer patients that respond to immunotherapy treatments.

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Therapeutics