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Therapeutics

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Promising new bioactive material to regenerate cartilage

6 August 2024 | By Drug Target Review

A biomaterial that improved hyaline cartilage repair could be used to avoid knee replacements and treat injuries and degenerative diseases.

article

Exploring the potential of ADCs beyond oncology

6 August 2024 | By Mike Ward (Clarivate)

Antibody Drug Conjugates (ADCs) are already deployed as part of the roster of oncology treatments, but here, Mike Ward, Head of Thought Leadership for Life Sciences & Healthcare, Clarivate, looks into their potential to help treat a whole range of other diseases and conditions. He discusses the barriers and enablers…

article

Restoring TERT to attenuate ageing hallmarks

2 August 2024 | By Dr Ronald DePinho (UT MD Anderson Cancer Center)

In this Q&A, Dr Ronald DePinho of MD Anderson elucidates their preclinical proof-of-concept that adjusting TERT levels could be a viable therapeutic approach for mitigating age-related diseases, such as cancer, heart disease and Alzheimer’s.

news

Spinal muscular atrophy: searching for a cure

1 August 2024 | By Drug Target Review

Organoids with SMA-pathology uncovered key findings about the disease, which could be utilised to develop new therapeutic options.

podcasts

How mRNA technology could revolutionise therapeutics

29 July 2024 | By Drug Target Review

In this episode, we explore how mRNA technology could revolutionise cancer therapeutics.

news

Mini-lungs enable breakthroughs in SARS-CoV-2 research

29 July 2024 | By Drug Target Review

Researchers discovered two potential new drug applications with the possible clinical use of surfactant early in COVID-19 cases.

article

Supercharging conventional monoclonal antibodies

29 July 2024 | By Dennis Pedersen (Commit Biologics), Drug Target Review, Krishna Polu (Commit Biologics)

In this Q&A, Krishna Polu and Dennis Pedersen, senior leaders of Commit Biologics, which is backed by Novo Holdings and Bioqube Ventures, elucidate how their technology differs from other existing therapeutic platforms and highlight its implications for the treatment of both cancer and autoimmune disease.

news

New agreement to progress cardiovascular disease research

26 July 2024 | By Drug Target Review

The agreement between Cartherics, The University of Sydney and The University of Queensland will further stem cell-derived heart muscle therapy for heart failure.

news

The role of KDR in the survival of HTLV-1-infected T cells

23 July 2024 | By Drug Target Review

KDR inhibitors could be very impactful for treatment of ATLL and HAM/TSP or prevent disease by lessening the viral load of HTLV-1.

news

Predicting persistent taxane-induced peripheral neuropathy

15 July 2024 | By Drug Target Review

Researchers have developed a prediction model to ascertain breast cancer survivors’ risk of persistent taxane-induced peripheral neuropathy.

news

Rare types of helper T cells uncovered

12 July 2024 | By Drug Target Review

Researchers have created a new T cell atlas which could aid the development of novel drug therapies for immune-mediated diseases.

news

Elucidating the pathophysiology of migraines

11 July 2024 | By Drug Target Review

Researchers show that proteins released from the brain during migraine with aura are transported by CSF to pain-signalling nerves.

article

Could illuminating the surfaceome help find new targeted cancer therapies?

11 July 2024 | By Roman Thomas (DISCO Pharmaceuticals)

At the heart of precision oncology is the need to increase our understanding and knowledge of surface proteins found on tumour cells. Here Roman Thomas, CEO of DISCO Pharmaceuticals, explains how it is using cutting-edge technology to explore the surfaceome – a map of the proteins on the cell’s surface…

news

Overcoming chemotherapy resistance in pancreatic cancer

10 July 2024 | By Drug Target Review

Researchers have discovered that pancreatic cancer’s resistance to chemotherapy is related to the physical stiffness of the extracellular matrix.

Women scientists nurses and doctors fighting against coronavirus. Feminist steminist illustration. Female Doctors, nurses and scientists together.

article

Women in Stem with Morgane Rousselot

3 July 2024 | By Morgane Rousselot (SeaBeLife)

We had the privilege of speaking to Morgane Rousselot, co-founder and CEO of SeaBeLife for our Women in Stem series. With a strong scientific background and over two decades of entrepreneurial experience in the biotechnology field, she leads the company with a team-focused approach and intellectual rigor.

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Therapeutics