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Therapeutics

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Network modelling reveals a potential new Alzheimer’s therapy

25 November 2020 | By Hannah Balfour (Drug Target Review)

Researchers used integrative network biology analysis to identify the molecular mechanisms that may drive Alzheimer’s and identified a potential therapeutic intervention.

cartoon of the cross-section of a purple ion channel in a blue lipid bylayer (plasma mebrane)

news

New insight to guide discovery of drugs targeting ion channels

24 November 2020 | By Hannah Balfour (Drug Target Review)

The study shows how drug-like small molecules inhibit the activity of Transient Receptor Potential Canonical 1/4/5 (TRPC1/4/5) channels and could transform the development of future therapies.

news

Novel inhibitor kills brain cancer cells missing ENO1 in mice, study shows

24 November 2020 | By Victoria Rees (Drug Target Review)

In pre-clinical studies, researchers have shown that a new therapy called POMHEX can destroy brain cancer cells that were missing one of two genes encoding the enolase enzyme.

cartoon of two hips and femurs - left on with large black dots in the bone indicating osteoporosis (bone being removed and becoming spongy), the other with smaller dots indicating normal bone

news

MALP cells as a potential target for osteoporosis drug development

23 November 2020 | By Hannah Balfour (Drug Target Review)

Researchers have found that bone marrow adipogenic lineage precursor (MALP) cells may initiate the production of osteoclasts and drive bone remodelling in osteoporosis.

white antibodies attacking an orange coronavirus particle with yellow neuraminidase proteins on its surface

news

Antibody effector functions are key to combatting COVID-19, finds study

23 November 2020 | By Hannah Balfour (Drug Target Review)

Rodent studies show that using antibodies with different targets and modes of action in combination is more effective at preventing and treating COVID-19.

hand holding a black rimmed magnifying glass over a DNA strand - idea of genetic research

news

Mutated PCSK9 gene protects against liver damage and cardiovascular disease, say researchers

20 November 2020 | By Hannah Balfour (Drug Target Review)

Scientists suggest the PCSK9Q152H gene variant may act as a “fountain of youth”, allowing people to live longer, healthier lives.

news

Compound that prevents replication of SARS-CoV-2 identified by researchers

20 November 2020 | By Victoria Rees (Drug Target Review)

Researchers say that the Ebselen compound can inhibit the replication of SARS-CoV-2 in the laboratory, so could combat COVID-19.

news

Researchers identify potential compound to inhibit inflammation

20 November 2020 | By Victoria Rees (Drug Target Review)

Researchers have found a compound that can prevent up-regulation of CD14, a key inflammatory protein, in cells.

cartoon of a syringe with white blobs coming out of it to attack yellow cancerous cells in tissue - idea of a cancer vaccine

article

Developing an effective vaccine for breast cancer

20 November 2020 | By Hannah Balfour (Drug Target Review)

This article summarises the development and testing of a novel vaccine that could be personalised for the treatment of immunotherapy-resistant cancers, such as triple-negative breast cancer (TNBC).

blue strands of DNA, central one with double-stranded cut, on a purple gradient background - idea of CRISPR genome editing

news

CRISPR-based treatment successfully targets glioblastoma and ovarian cancers in vivo

19 November 2020 | By Hannah Balfour (Drug Target Review)

Researchers say this is the first time that CRISPR-Cas9 gene editing has been used to treat cancer effectively in a living animal and that the technique could be revolutionary.

pile of colourful medication tablets with a central white tablet labelled 'hydroxychloroquine'

news

Researchers identify three drugs that could be repurposed for COVID-19

19 November 2020 | By Hannah Balfour (Drug Target Review)

The candidates were screened based on their similarity to hydroxychloroquine and tested for efficacy against SARS-CoV-2 in vitro.

news

Potential strategy to treat COVID-19-related cytokine storms identified

19 November 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that neutralising antibodies for the TNF-alpha and IFN-gamma cytokines can prevent death from SARS-CoV-2 in mice.

Woman sat at a microscope in a lab surrounded by chemical structure diagrams

news

Novel synthetic method enables production of cytotoxic compounds

18 November 2020 | By Hannah Balfour (Drug Target Review)

Researchers say their new process enables the synthesis of phenazinones, some of which have high selective toxicity for cancer cells and could be promising anticancer drugs in future.

news

CBD molecule has potential to treat rare skin diseases, study shows

17 November 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that CBD induces an enzyme with antioxidant and anti-inflammatory properties in the top layer of the skin.

cancerous cell with crosshares over it - idea of targetted cancer therapy

news

LMTK3 inhibitors could be an effective breast cancer therapy, say scientists

16 November 2020 | By Hannah Balfour (Drug Target Review)

Researchers demonstrate that inhibiting the LMTK3 kinase is an effective anticancer strategy in murine models of breast cancer.

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Therapeutics