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Therapeutics

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Researchers identify lead compounds for treatment of telomere diseases

23 April 2020 | By Victoria Rees (Drug Target Review)

Researchers investigating telomere dieases such as dyskeratosis congenita have found lead compounds that reverse cellular ageing in mouse models of the condition.

scientists in personal protective equipment looking at samples labelled COVID-19 under a microscope

news

Fundamental molecular research underpins our ability to combat COVD-19, says article

23 April 2020 | By Hannah Balfour (Drug Target Review)

Ali Shilatifard’s article explains how investment in institutes performing molecular research is essential, as it is the foundation for all attempts to combat COVID-19 and other future pandemics.

white blob representing a Natural Killer T cell attaching an orange cancer cell on a red tissue-like background

article

Developing immunotherapies for hard-to-treat cancers

23 April 2020 | By Hannah Balfour (Drug Target Review)

Exploring how therapies with multi-faceted approaches could improve options for treatment-refractory cancers, like pancreatic and triple-negative breast cancer.

long thin filament-like viral particle in brown with blue surface glycoproteins that look like polka dots

news

Experiments with Marburg virus reveal novel antibody protective mechanisms

22 April 2020 | By Hannah Balfour (Drug Target Review)

Researchers discovered the monoclonal antibodies of a convalescent Marburg infection patient bound to the glycoprotein and combatted infection in two novel ways.

news

Novel antibody treatment for OCD demonstrates efficacy in mice

22 April 2020 | By Victoria Rees (Drug Target Review)

Researchers who administered an antibody to neutralise an OCD-associated protein in mice found it reduced their anxious behaviours.

purple papillomavirus particles on a pink 'tissue'-like background

news

Glycomimetics could prevent COVID-19 from infecting human cells

21 April 2020 | By Hannah Balfour (Drug Target Review)

Glycomimetics, a novel class of antivirals, prevented influenza, herpes viruses and papillomaviruses from infecting cells in animal models and could show similar efficacy against COVID-19.

news

UK government funds 21 new research projects into COVID-19

20 April 2020 | By Victoria Rees (Drug Target Review)

A total of 21 COVID-19 research projects have been granted funding by the UK government, including vaccine and therapeutic development.

strands of DNA contained withing blue and white capsules, on a dark blue background

news

Novel gene promoters could improve gene therapies for neurological diseases

20 April 2020 | By Hannah Balfour (Drug Target Review)

Novel promoters based on those in the herpes viruses, enabled delivery of larger genes and increased the period they were active in the nervous system.

tablets, capsules and a laboratory scientist in a white coat on a swirling blue background

news

Screening 10,000 compounds identifies six potential COVID-19 therapeutics

17 April 2020 | By Hannah Balfour (Drug Target Review)

High-throughput screening of thousands of compounds has revealed several candidates, including lead compound ebselen, with the potential for treating COVID-19.

article

High-throughput screening for antibody-based drugs

16 April 2020 | By Victoria Rees (Drug Target Review)

A collaboration between academia and industry has produced an assay and new screening technique which utilises directed evolution for the discovery of antibody-based drugs.

woman undergoing radiation for brain cancer

news

Drug could prevent cognitive decline associated with brain tumour radiation

16 April 2020 | By Hannah Balfour (Drug Target Review)

Researchers demonstrated NSPP completely prevented cognitive decline in mice treated with radiation for patient-derived glioblastomas.

news

Researchers reveal how remdesivir prevents COVID-19 viral replication

15 April 2020 | By Victoria Rees (Drug Target Review)

According to a new study, the drug remdesivir is a very potent inhibitor for coronavirus polymerases - demonstrating its potential for combatting COVID-19.

drug capsule repelling coronavirus particles

news

COVID-19 Drug Repurposing Database made open-access by Excelra

15 April 2020 | By Hannah Balfour (Drug Target Review)

The enterprise revealed that it has made its COVID-19 Drug Repurposing Database open-access to aid in the search for an effective therapeutic.

Mesenchymal stem cells as COVID-19 therapy

article

Mesenchymal stem cells secretome as a prospective therapeutic option for COVID-19 patients

13 April 2020 | By Avinash Kharat (Dr D Y Patil Vidyapeeth), Avinash Sanap ( Dr D Y Patil Vidyapeeth), Dr Ramesh Bhonde (Dr D Y Patil Vidyapeeth), Supriya Kheur (Dr D Y Patil Vidyapeeth)

Researchers propose using mesenchymal stem cells to counter the pro-inflammatory cytokines associated with COVID-19 coronavirus symptoms.

sagittal (side through view) magnetic resonance image of the brain with skull and supporting structures in purple and brain and brainstem in red and orange

article

Refreshing how we approach neuroscience with a novel screening technology

9 April 2020 | By Hannah Balfour (Drug Target Review)

Drug Target Review discusses how NETSseq, a novel profiling technology, is bringing new insights to neurodegenerative and psychiatric diseases.

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Therapeutics