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Triple-negative breast cancer could be treated using experimental treatment
A mouse study has revealed that triple-negative breast cancer could be tackled by using recombinant Tinagl1 in therapy targeting signalling pathways...
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Therapeutics
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The mysterious functions of the PCSK9 protein
Researchers have described the methods used to build a model of the 'druggable' PCSK9 inhibitor and detailed how it works...
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Implantable device could treat bladder problems
A tiny, soft, implantable device could be used to treat and control bladder problems, such as incontinence or the need to frequently urinate...
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Using machine learning to predict symptoms
Machine learning could, in future, be the way that clinicians decide on particular courses of treatments for patients affected by cancer...
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Potential drug targets found by muting large silent genes
Streptomyces bacteria has been used to identify compounds that could lead to the production of drugs to treat various conditions...
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Application note: Rapidly isolate high-producing clones
Find out how to streamline Cell Line Development by identifying high-producing clones with monoclonality assurance in one day.
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Drug targets for Dengue, Zika and Ebola viruses
US researchers have identified possible drug targets for Dengue, Zika and Ebola viruses…
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Vaccine could combat opioid addiction and reduce deaths
Researchers have developed a vaccine to combat the opioid epidemic and to prevent deaths, with possible applications of the vaccine in many areas...
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Ingestible capsule controlled wirelessly could treat diseases
Researchers have designed a drug delivery capsule that can stay in the stomach for up to 1 month, and could sense and treat infections...
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Calcium carbonate sprayable gel could fight cancer
A sprayable gel containing calcium carbonate nanoparticles with an antibody specifically targeted to block CD47, could be the future of cancer treatments...
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Beyond ‘simple’ biology – turning organoids, spheroids, and 3D tissue models into physiologically relevant high-content assays for drug discovery
Drug discovery is still hampered by the routine use of cell-based models that often fail to recapitulate the truly relevant biological complexity of the corresponding disease. Just moving from two- (2D) towards three-dimensional (3D) cell culture model systems like spheroids and organoids is not enough to generate truly representative and…
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Phospholipid reactive T-cells could play a role in cancer
Phospholipid-reactive T-cells that are able to recognise phospholipids could help in treatments against cancer, autoimmune diseases and dyslipidemia...
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Expert view: Challenges in drug discovery screening
The basic premise of drug discovery screening necessitates that the biological assays upon which it depends can be performed in a reproducible manner. In addition, the techniques employed must generate results that are biologically relevant and actionable.
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Frizzled receptors could be drug targets for treating major diseases
Frizzled receptors, from the GPCR family, could soon be a target to treat numerous diseases such as cancer, fibrosis and CVD...
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PAINS management: an open source model to eliminate nuisance compounds
High-throughput screening (HTS) technologies have enabled the routine testing of millions of compounds towards the identification of novel ‘hit’ molecules for therapeutic targets. Oftentimes in this drug discovery process, however, compounds that show promising activity in primary screens show no activity during subsequent hit qualification or progression efforts.
