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Gene therapy to reduce deafness in mice
Gene therapy has been used to restore hearing in an adult mouse model of DFNB9 deafness, one of the most frequent cases of congenital genetic deafness...
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Therapeutics
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Fighting HIV using anti-cancer immunotherapy
Researchers have used immunotherapy treatments, ordinarily used to treat cancer, to reveal the virus in the cells of people living with HIV...
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How the immune cell ‘Iron Man’ helps T-cells fight infection
The Iron Man of immune cells, the CD4 cell, has been found to help T-cells fight viral infections, with a lack of these cells often leading to illness...
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Immunotherapy and DNA damage repair combo could target lung cancer
Combination therapy with a CHK1 or PARP inhibitor, with an immune checkpoint inhibitor caused the regression of small cell lung cancer in all mice treated...
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Live-imaging technique reveals cellular plug for leaky bio barrier
A microscopy assay has shown the repair mechanism involved in the activation of a protein called Rho, used to plug leaky biological barriers in the body...
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Reprogramming stem cells using the measles virus vector
A method has been developed to reprogram stem cells using the measles virus vector, cutting a four-step process to only one stage...
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Reversible antiplatelet therapy fights cancer metastasis and clotting
A novel antiplatelet therapy could help to prevent heart attacks and stroke through preventing the formation of blood clots...
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Development of a gel for liver cell culture on microchips
Hydrogels could be used to build organs on chips to test potential medications, with the aim that they could potentially replace animal studies...
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Diagnostic technique reveals biomarker differentiating bladder cancer from inflammation
A biomarker that can differentiate between chronic cystitis (inflammation of the bladder) and a non-muscle invasive-type blood cancer could aid diagnosis...
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Genomic approach to studying widespread malaria
Researchers have suggested that the most widespread human malaria parasite could be studied and possibly treated using genomics...
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Protecting vision after optic nerve trauma using arginase 2
Arginase 2 could be used as a drug target target to protect vision after optic nerve trauma, as removal of this enzyme decreases retinal neuron death...
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Functional transplantable B-cells generated from mice
Stem cells generated from mice have shown to be functional when transplanted, leading to the possibility of future therapies...
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Protection against Mayaro virus using engineered DNA vaccine
An engineered DNA vaccine that induces a robust and specific immune response against the disease, also provides complete protection...
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The role of immune cells in metastasis
Specific immune cells, such as neutrophils, have been found to aid the progression of cancers, promoting metastasis in tumours...
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Key function of specialised cells in peripheral nerve repair
The interaction between macrophages and Schwann cells could be vital in maintaining the repair process, without which could impair nerve function...
